Phenotypic Characteristics of CD8+ T Cells in the PB and the Lung of HIV-Infected Patients and Healthy Subjects Both at Resting Conditions and After a 12-Hour Exposure to IL-15
| T-Cell Subsets . | CD45RA . | CD45R0 . | CD69 . | HLA-DR . | ||||
|---|---|---|---|---|---|---|---|---|
| . | At Resting Conditions . | After 12-h IL-15 Exposure . | At Resting Conditions . | After 12-h IL-15 Exposure . | At Resting Conditions . | After 12-h IL-15 Exposure . | At Resting Conditions . | After 12-h IL-15 Exposure . |
| . | % . | % . | % . | % . | % . | % . | % . | % . |
| HIV-infected patients | ||||||||
| PB CD8+ T cells | 38.3 ± 6.1 | 21.2 ± 5.4 | 47.1 ± 3.9 | 69.3 ± 5.2 | 5.2 ± 3.0 | 47.1 ± 7.5 | 7.4 ± 2.7 | 46.3 ± 5.3 |
| Pulmonary CD8+ T cells | 3.3 ± 1.4 | 0.1 ± 0.6 | 91.3 ± 5.3 | 98.2 ± 2.7 | 65.4 ± 5.8 | 87.3 ± 4.0 | 70.2 ± 5.2 | 93.3 ± 4.0 |
| Controls | ||||||||
| PB CD8+ T cells | 52.1 ± 4.2 | 33.1 ± 3.9 | 39.4 ± 4.2 | 66.1 ± 4.1 | 3.4 ± 1.1 | 78.6 ± 6.1 | 1.1 ± 0.3 | 69.6 ± 5.9 |
| Pulmonary CD8+ T cells | 4.1 ± 0.9 | 0.4 ± 0.4 | 84.1 ± 6.0 | 97.1 ± 2.0 | 21.4 ± 3.6 | 56.4 ± 4.6 | 22.4 ± 3.2 | 67.7 ± 7.0 |
| T-Cell Subsets . | CD45RA . | CD45R0 . | CD69 . | HLA-DR . | ||||
|---|---|---|---|---|---|---|---|---|
| . | At Resting Conditions . | After 12-h IL-15 Exposure . | At Resting Conditions . | After 12-h IL-15 Exposure . | At Resting Conditions . | After 12-h IL-15 Exposure . | At Resting Conditions . | After 12-h IL-15 Exposure . |
| . | % . | % . | % . | % . | % . | % . | % . | % . |
| HIV-infected patients | ||||||||
| PB CD8+ T cells | 38.3 ± 6.1 | 21.2 ± 5.4 | 47.1 ± 3.9 | 69.3 ± 5.2 | 5.2 ± 3.0 | 47.1 ± 7.5 | 7.4 ± 2.7 | 46.3 ± 5.3 |
| Pulmonary CD8+ T cells | 3.3 ± 1.4 | 0.1 ± 0.6 | 91.3 ± 5.3 | 98.2 ± 2.7 | 65.4 ± 5.8 | 87.3 ± 4.0 | 70.2 ± 5.2 | 93.3 ± 4.0 |
| Controls | ||||||||
| PB CD8+ T cells | 52.1 ± 4.2 | 33.1 ± 3.9 | 39.4 ± 4.2 | 66.1 ± 4.1 | 3.4 ± 1.1 | 78.6 ± 6.1 | 1.1 ± 0.3 | 69.6 ± 5.9 |
| Pulmonary CD8+ T cells | 4.1 ± 0.9 | 0.4 ± 0.4 | 84.1 ± 6.0 | 97.1 ± 2.0 | 21.4 ± 3.6 | 56.4 ± 4.6 | 22.4 ± 3.2 | 67.7 ± 7.0 |