Table 1. Kinetic Parameters of... | American Society of Hematology

Table 1.

Kinetic Parameters of Chromogenic Substrate S-2366 Cleavage and Human Factor IX Activation by Recombinant Human and Murine Factor XIa

Enzyme	S-2366		Factor IX
	K_m	k_cat (min⁻¹)	K_m	k_cat (min⁻¹)	k_cat /K_m
	(μmol/L)		(nmol/L)

Human factor XIa	260	130	216	3.5	16.2
Murine factor XIa	190	37	147	1.5	10.2

Enzyme	S-2366		Factor IX
	K_m	k_cat (min⁻¹)	K_m	k_cat (min⁻¹)	k_cat /K_m
	(μmol/L)		(nmol/L)

Human factor XIa	260	130	216	3.5	16.2
Murine factor XIa	190	37	147	1.5	10.2