Table 1. Hemostasis Parameters and... | American Society of Hematology

Table 1.

Hemostasis Parameters and Molecular Genetic Findings in Two Families With Ligneous Conjunctivitis

Subjects	Fibrinogen (mg/dL)^*	t-PA (ng/mL)^†	PAI-1 (U/mL)^‡	Plasminogen Activity (%)ρ	Plasminogen Antigen	Mutations in the Plasminogen Gene
					(mg/dL)^1-154	First Allele/Second Allele
Family 1
Patient 1 (II-1)	346	5.0	10.6	6.0	<0.4	Arg₂₁₆ → His/Arg₂₁₆ → His
Mother (I-1)	249	3.0	3.5	66	2	Arg₂₁₆ → His/Wild type
Father (I-2)	306	6.2	3.0	60	7	Arg₂₁₆ → His/Wild type
Sister (II-2)	289	3.6	8.0	76	7.5	Arg₂₁₆ → His/Wild type
Family 2
Patient 2 (II-1)	400	2.0	3.1	<5	<0.4	Trp₅₉₇ → Stop/Trp₅₉₇ → Stop
Mother (I-1)	250	3.7	3.1	60	5.2	Trp₅₉₇ → Stop/Wild type
Father (I-2)	240	1.1	3.1	15	1.2	Trp₅₉₇ → Stop/Trp₅₉₇ → Cys
Sister (II-2)	330	2.0	0.89	66	6.9	Wild type/Trp₅₉₇ → Cys

Subjects	Fibrinogen (mg/dL)^*	t-PA (ng/mL)^†	PAI-1 (U/mL)^‡	Plasminogen Activity (%)ρ	Plasminogen Antigen	Mutations in the Plasminogen Gene
					(mg/dL)^1-154	First Allele/Second Allele
Family 1
Patient 1 (II-1)	346	5.0	10.6	6.0	<0.4	Arg₂₁₆ → His/Arg₂₁₆ → His
Mother (I-1)	249	3.0	3.5	66	2	Arg₂₁₆ → His/Wild type
Father (I-2)	306	6.2	3.0	60	7	Arg₂₁₆ → His/Wild type
Sister (II-2)	289	3.6	8.0	76	7.5	Arg₂₁₆ → His/Wild type
Family 2
Patient 2 (II-1)	400	2.0	3.1	<5	<0.4	Trp₅₉₇ → Stop/Trp₅₉₇ → Stop
Mother (I-1)	250	3.7	3.1	60	5.2	Trp₅₉₇ → Stop/Wild type
Father (I-2)	240	1.1	3.1	15	1.2	Trp₅₉₇ → Stop/Trp₅₉₇ → Cys
Sister (II-2)	330	2.0	0.89	66	6.9	Wild type/Trp₅₉₇ → Cys

Fibrinogen (normal range, 180-450 mg/dL).

Tissue-type plasminogen activator (normal range, 1-12 ng/mL).

Plasminogen activator inhibitor type 1 (normal, <10 U/mL).

ρ Plasminogen activity (normal range, 80%-120%).

Plasminogen antigen (normal range, 6-25 mg/dL).