Clinical and Molecular Outcome of 16 Patients Withdrawn From Study Due To Therapy-Related Toxicity
| UPN . | Age . | No. of Consolid. Cycles Received . | Type of Toxicity . | Further Therapy Postconsolid. . | Outcome . | Follow-up RT-PCR Analyses . |
|---|---|---|---|---|---|---|
| 28024 | 65 | 04-150 | Cardiac | ATRA/MTX/6MP | CCR 14+4-151 | Negative (2 tests) |
| 28030 | 60 | 0 | Infectious | ATRA/MTX/6MP | CCR 10+ | Negative (2 tests) |
| 04003 | 63 | 1 | Infectious | IFN | CCR 33+ | Negative (3 tests) |
| 10004 | 62 | 1 | Infectious | None | Relapsed at 6 mo/dead | Negative (2 tests) |
| 35003 | 55 | 2 | Neurologic | None | CCR 31+ | Negative (5 tests) |
| 04002 | 33 | 2 | Infectious | ATRA/MTX/6MP | CCR 32+ | Negative (3 tests) |
| 36001 | 59 | 2 | Infectious | IFN | CCR 32+ | Negative (4 tests) |
| 28015 | 63 | 2 | Prolonged BM hypoplasia | MTX/6MP | CCR 33+ | Negative (6 tests) |
| D6004 | 9 | 2 | Severe mucositis | None | CCR 29+ | Negative (6 tests) |
| 43002 | 66 | 2 | Prolonged BM hypoplasia | None | CCR 29+ | Negative (4 tests) |
| 37005 | 62 | 2 | Prolonged BM hypoplasia | None | CCR 30+ | Negative (5 tests) |
| 55001 | 43 | 2 | Infectious | None | Relapsed at 7 mo/dead | Positive after ind.‡ |
| 07006 | 63 | 2 | Infectious | None | Dead at 2 moρ | Negative (1 test) |
| 43005 | 66 | 2 | Neurologic | None | CCR 16+ | Negative (3 tests) |
| 28021 | 23 | 2 | Infectious | MTX/6MP | CCR 17+ | Negative 5 tests, 1 +ve 4-155 |
| 08005 | 31 | 2 | Infectious | None | CCR 10+ | Negative (3 tests) |
| UPN . | Age . | No. of Consolid. Cycles Received . | Type of Toxicity . | Further Therapy Postconsolid. . | Outcome . | Follow-up RT-PCR Analyses . |
|---|---|---|---|---|---|---|
| 28024 | 65 | 04-150 | Cardiac | ATRA/MTX/6MP | CCR 14+4-151 | Negative (2 tests) |
| 28030 | 60 | 0 | Infectious | ATRA/MTX/6MP | CCR 10+ | Negative (2 tests) |
| 04003 | 63 | 1 | Infectious | IFN | CCR 33+ | Negative (3 tests) |
| 10004 | 62 | 1 | Infectious | None | Relapsed at 6 mo/dead | Negative (2 tests) |
| 35003 | 55 | 2 | Neurologic | None | CCR 31+ | Negative (5 tests) |
| 04002 | 33 | 2 | Infectious | ATRA/MTX/6MP | CCR 32+ | Negative (3 tests) |
| 36001 | 59 | 2 | Infectious | IFN | CCR 32+ | Negative (4 tests) |
| 28015 | 63 | 2 | Prolonged BM hypoplasia | MTX/6MP | CCR 33+ | Negative (6 tests) |
| D6004 | 9 | 2 | Severe mucositis | None | CCR 29+ | Negative (6 tests) |
| 43002 | 66 | 2 | Prolonged BM hypoplasia | None | CCR 29+ | Negative (4 tests) |
| 37005 | 62 | 2 | Prolonged BM hypoplasia | None | CCR 30+ | Negative (5 tests) |
| 55001 | 43 | 2 | Infectious | None | Relapsed at 7 mo/dead | Positive after ind.‡ |
| 07006 | 63 | 2 | Infectious | None | Dead at 2 moρ | Negative (1 test) |
| 43005 | 66 | 2 | Neurologic | None | CCR 16+ | Negative (3 tests) |
| 28021 | 23 | 2 | Infectious | MTX/6MP | CCR 17+ | Negative 5 tests, 1 +ve 4-155 |
| 08005 | 31 | 2 | Infectious | None | CCR 10+ | Negative (3 tests) |
Abbreviations: MTX, methotrexate; 6MP, 6-mercaptopurine; IFN, alpha 2b interferon.
Patients 1 and 2 received induction therapy only.
Months in continuous complete remission.
Tested after induction therapy only.
ρ Died of septic shock while in CR.
Tested PCR-positive at the last molecular follow-up analysis.