Binding of Human IgG Subclasses of NK Cells From Individuals Genotyped for FcγRIIIA Polymorphisms (MFI ± SD)
| Genotype . | Subclass . | |||||
|---|---|---|---|---|---|---|
| FcγRIIIA-48 . | FcγRIIIA-158 . | IgG1 . | IgG2 . | IgG3 . | IgG4 . | Cytophilic IgG . |
| 48LL | 158FF | 913 ± 317 | 58 ± 33 | 390 ± 131 | 106 ± 104 | 337 ± 159 |
| 48LL | 158VF | 1,257 ± 608 | 124 ± 126 | 912 ± 2863-150 | 413 ± 178 | 695 ± 405 |
| 48LR or 48LH | 158VF | 1,243 ± 194 | 155 ± 133 | 746 ± 230 | 548 ± 202 | 1,139 ± 542 |
| 48LR or 48LH | 158VV | 1,814 ± 5073-151 | 173 ± 98 | 1,053 ± 487 | 487 ± 286 | 1,788 ± 796 |
| Genotype . | Subclass . | |||||
|---|---|---|---|---|---|---|
| FcγRIIIA-48 . | FcγRIIIA-158 . | IgG1 . | IgG2 . | IgG3 . | IgG4 . | Cytophilic IgG . |
| 48LL | 158FF | 913 ± 317 | 58 ± 33 | 390 ± 131 | 106 ± 104 | 337 ± 159 |
| 48LL | 158VF | 1,257 ± 608 | 124 ± 126 | 912 ± 2863-150 | 413 ± 178 | 695 ± 405 |
| 48LR or 48LH | 158VF | 1,243 ± 194 | 155 ± 133 | 746 ± 230 | 548 ± 202 | 1,139 ± 542 |
| 48LR or 48LH | 158VV | 1,814 ± 5073-151 | 173 ± 98 | 1,053 ± 487 | 487 ± 286 | 1,788 ± 796 |
At least three donors of each genotype were tested. Data were analyzed with the Student's t-test and the Welch's approximate t-test. P values below .05 were considered significant.
Statistically significant difference from IgG3 binding by NK cells from FcγRIIIa-158F/F individuals of the same FcγRIIIA-48 genotype.
Significantly different from FcγRIIIa-158V/F cells of the same FcγRIIIA-48 genotype.