CD16 MoAb Binding (mean fluorescence intensities ± SD) of NK Cells From Individuals Genotyped for FcγRIIIA Polymorphisms
| Genotype . | MoAb . | ||||
|---|---|---|---|---|---|
| FcγRIIIA-48 . | FcγRIIIA-158 . | Control mIgG2a . | CLBFcRgran1 . | MEM154 . | B73.1 . |
| 48LL | 158FF | 12 ± 6 | 1,539 ± 257 | 42 ± 20 | 303 ± 176 |
| 48LL | 158VF | 8 ± 4 | 1,713 ± 719 | 460 ± 218* | 248 ± 105 |
| 48LR or 48LH | 158VF | 6 ± 2 | 1,443 ± 504 | 323 ± 182 | 121 ± 51† |
| 48LR or 48LH | 158VV | 10 ± 5 | 1,102 ± 298 | 718 ± 341‡ | 151 ± 117 |
| 48HH ρ | 158VV | 7 | 1,694 | 892 | 55 |
| 48RR2-155 | 158VV | 15 | 1,443 | 642 | 103 |
| Genotype . | MoAb . | ||||
|---|---|---|---|---|---|
| FcγRIIIA-48 . | FcγRIIIA-158 . | Control mIgG2a . | CLBFcRgran1 . | MEM154 . | B73.1 . |
| 48LL | 158FF | 12 ± 6 | 1,539 ± 257 | 42 ± 20 | 303 ± 176 |
| 48LL | 158VF | 8 ± 4 | 1,713 ± 719 | 460 ± 218* | 248 ± 105 |
| 48LR or 48LH | 158VF | 6 ± 2 | 1,443 ± 504 | 323 ± 182 | 121 ± 51† |
| 48LR or 48LH | 158VV | 10 ± 5 | 1,102 ± 298 | 718 ± 341‡ | 151 ± 117 |
| 48HH ρ | 158VV | 7 | 1,694 | 892 | 55 |
| 48RR2-155 | 158VV | 15 | 1,443 | 642 | 103 |
At least three donors of each genotype were tested. Data were analyzed with the Student's t-test the and Welch's approximate t-test. P values below .05 were considered significant.
Statistically significant difference from mean fluorescence intensity of NK cells from FcγRIIIa-158FF individuals of the same FcγRIIIA-48 genotype.
Significantly different from FcγRIIIa-48LL NK cells of the same FcγRIIIA-158 genotype.
Significantly different from FcγRIIIa-158VF NK cells of the same FcγRIIIA-48 genotype.
ρ Two individuals were tested; one healthy control and one patient suffering from recurrent viral infections.
One healthy individual was tested.