Fcγ RIIIA-158V/F Genotypes in White Individuals (n = 87), Typed for Fcγ RIIIA-48L/R/H
| FcγRIIIa-158 . | FcγRIIIa-48L/R/H Phenotype . | |||||||
|---|---|---|---|---|---|---|---|---|
| Genotype . | Phenotype . | Total . | 48LL . | 48LR . | 48LH . | 48RR . | 48HH . | 48RH . |
| 559T/T | 158FF | 28 | 28 | — * | — | — | — | — |
| 559G/T | 158VF | 44 | 34 | 4 | 6 | — | — | — |
| 559G/G | 158VV | 15 | 4 | 6 | 4 | 1 | — † | — |
| FcγRIIIa-158 . | FcγRIIIa-48L/R/H Phenotype . | |||||||
|---|---|---|---|---|---|---|---|---|
| Genotype . | Phenotype . | Total . | 48LL . | 48LR . | 48LH . | 48RR . | 48HH . | 48RH . |
| 559T/T | 158FF | 28 | 28 | — * | — | — | — | — |
| 559G/T | 158VF | 44 | 34 | 4 | 6 | — | — | — |
| 559G/G | 158VV | 15 | 4 | 6 | 4 | 1 | — † | — |
Gene frequencies are 0.57 and 0.43 for FcγRIIIa-158F and FcγRIIIa-158V, respectively. A clear linkage was observed between the FcγRIIIA-158F and the FcγRIIIA-48L alleles, as well as between the FcγRIIIa-158V and either the FcγRIIIa-48R or −48H alleles (χ 2 test; P < .001 in both cases).
A dash ( — ) denotes that in this study none of the tested donors had this genotype.
In a previous study we described one healthy individual and two unrelated patients suffering from recurrent bacterial and viral infections who were homozygous FcγRIIIa-48H/H (De Vries, unpublished data, 1996 and ref 18). These three donors were found to be homozygous FcγRIIIa-158VV.