Characteristics of 11 Children Who Developed MDS/AML
| Patients . | Age . | Gender . | Etiology . | Severity . | Interval AA to MDS/AML (mo) . | FAB Classification MDS/AML . | Cytogenetic Study . | Treatment for MDS/AML and Outcome . | |
|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | . | . | . | . | . |
| 1 | 13 | M | idiop | vS | 74 | RA | −7,+21 | U-BMT | Dead |
| 2 | 14 | M | idiop | vS | 61 | RA | −7 | Alive | |
| 3 | 16 | M | hepat | S | 38 | M4 | −7 | Dead | |
| 4 | 5 | M | idiop | S | 17 | RA/M4 | −7 | U-BMT | Dead |
| 5 | 3 | F | idiop | S | 30 | RAEB | +21 | BMT* | Dead |
| 6 | 3 | F | idiop | S | 32 | RA | −7 | Alive | |
| 7 | 5 | F | idiop | vS | 12 | RAEB | −7 | Dead | |
| 8 | 9 | F | idiop | vS | 15 | RAEBin T/M4 | −7 | U-BMT | Dead |
| 9 | 10 | M | idiop | vS | 23 | RAEBin T/M4 | −7 | Dead | |
| 10 | 2 | M | idiop | vS | 22 | RA | −7 | U-BMT | Alive |
| 11 | 7 | M | hepat | S | 25 | RAEBin T/M4 | −7/−7,+21 | U-BMT | Dead |
| Patients . | Age . | Gender . | Etiology . | Severity . | Interval AA to MDS/AML (mo) . | FAB Classification MDS/AML . | Cytogenetic Study . | Treatment for MDS/AML and Outcome . | |
|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | . | . | . | . | . |
| 1 | 13 | M | idiop | vS | 74 | RA | −7,+21 | U-BMT | Dead |
| 2 | 14 | M | idiop | vS | 61 | RA | −7 | Alive | |
| 3 | 16 | M | hepat | S | 38 | M4 | −7 | Dead | |
| 4 | 5 | M | idiop | S | 17 | RA/M4 | −7 | U-BMT | Dead |
| 5 | 3 | F | idiop | S | 30 | RAEB | +21 | BMT* | Dead |
| 6 | 3 | F | idiop | S | 32 | RA | −7 | Alive | |
| 7 | 5 | F | idiop | vS | 12 | RAEB | −7 | Dead | |
| 8 | 9 | F | idiop | vS | 15 | RAEBin T/M4 | −7 | U-BMT | Dead |
| 9 | 10 | M | idiop | vS | 23 | RAEBin T/M4 | −7 | Dead | |
| 10 | 2 | M | idiop | vS | 22 | RA | −7 | U-BMT | Alive |
| 11 | 7 | M | hepat | S | 25 | RAEBin T/M4 | −7/−7,+21 | U-BMT | Dead |
Abbreviations: BMT, bone marrow transplantation; idiop, idiopathic AA; hepat, posthepatitis AA; vS, very severe; S, severe; RA, refractory anemia; RAEB, refractory anemia with excess blasts; RAEBin T; refractory anemia with excess of blasts in transformation; M4, AML M4(FAB classification, Acute Myelomonocytic Leukemia); U-BMT, unrelated donor BMT; BMT*, 2 locus mismatch BMT from family donor.