Distribution of Mutations Within the VH-Genes, Based on the Dominant Clone in Each Biopsy Specimen
| Patient . | Biopsy . | R:Sobs (CDR) R:Sobs(FWR) . | Rexp(CDR) Rexp(FWR) . | p(CDR) p(FWR) . |
|---|---|---|---|---|
| BA | BA-1F | 3:4 = 0.75 | 5 | 0.21 |
| 9:6 = 1.5 | 13 | 0.054-150 | ||
| BA-2P | 1:3 = 0.3 | 5 | 0.10 | |
| 7:2 = 3.5 | 7 | 0.21 | ||
| EJ | EJ-1F | 4:1 = 4.0 | 4 | 0.22 |
| 10:5 = 2.0 | 11 | 0.14 | ||
| EJ-2F | 4:1 = 4.0 | 4 | 0.22 | |
| 11:5 = 2.2 | 12 | 0.15 | ||
| EJ-3F | 4:1 = 4.0 | 4 | 0.21 | |
| 9:5 = 1.8 | 11 | 0.12 | ||
| BR | BR-1P | 4:3 = 1.3 | 6 | 0.13 |
| 9:10 = 0.9 | 14 | 0.034-150 | ||
| BR-2F | 5:4 = 1.25 | 7 | 0.13 | |
| 13:17 = 0.76 | 22 | 0.014-150 |
| Patient . | Biopsy . | R:Sobs (CDR) R:Sobs(FWR) . | Rexp(CDR) Rexp(FWR) . | p(CDR) p(FWR) . |
|---|---|---|---|---|
| BA | BA-1F | 3:4 = 0.75 | 5 | 0.21 |
| 9:6 = 1.5 | 13 | 0.054-150 | ||
| BA-2P | 1:3 = 0.3 | 5 | 0.10 | |
| 7:2 = 3.5 | 7 | 0.21 | ||
| EJ | EJ-1F | 4:1 = 4.0 | 4 | 0.22 |
| 10:5 = 2.0 | 11 | 0.14 | ||
| EJ-2F | 4:1 = 4.0 | 4 | 0.22 | |
| 11:5 = 2.2 | 12 | 0.15 | ||
| EJ-3F | 4:1 = 4.0 | 4 | 0.21 | |
| 9:5 = 1.8 | 11 | 0.12 | ||
| BR | BR-1P | 4:3 = 1.3 | 6 | 0.13 |
| 9:10 = 0.9 | 14 | 0.034-150 | ||
| BR-2F | 5:4 = 1.25 | 7 | 0.13 | |
| 13:17 = 0.76 | 22 | 0.014-150 |
Abbreviations: R, replacement mutations; S, silent mutations.
Indicates statistical significance for conservation of sequence in FWR at a level of P ≤ .05. There was no significant clustering of R mutations in CDRs.