Characteristics of Relapse ALL Specimens
| No. . | Paired3-150 . | Age (yr)3-151 . | Sex . | Race . | WBC†‡ . | %Sρ . | % Blasts3-151 . | RD (mo)3-155 . | DHFR3-154 . | % . |
|---|---|---|---|---|---|---|---|---|---|---|
| rBP1 | BP20 | 8 | M | AA | 17,900 | NA | 95 | 8 | 6.9 | 100 |
| rBP2# | 15 | M | AA | 43,600 | NA | 96 | 9 | 2.4/14.8 | 75/25 | |
| rBP3# | 2 | F | W | 304,800 | NA | 75 | 5 | 1.6 | 100 | |
| rBP4# | 5 | M | W | 4,000 | NA | 90 | 36 | 4.3 | 100 | |
| rBP5# | 3.5 | M | W | 5,900 | NA | 95 | 45 | 2.0/6.9 | 60/40 | |
| rBP6# | BP9 | 4 | F | W | 23,000 | NA | 76 | 24 | 1.0 | 100 |
| rBP79# | 10 | M | W | 3,800 | NA | 80 | 19.5 | 1.5/12.3 | 16/84 | |
| rBP8 | 15.5 | M | W | 4,300 | NA | 70 | 27 | 4.9 | 100 | |
| rT1 | T2 | 14 | F | AA | 163,000 | NA | 61 | 10 | 7.9 | 100 |
| rT2 | T30 | 13.5 | M | W | 176,000 | NA | 80 | 12 | 2.1/19.6 | 22/78 |
| rT3# | 6 | M | W | 79,000 | NA | 90 | 15 | 2.1/15.1 | 59/41 | |
| rT4# | 5 | M | W | 3,800 | NA | 90 | 6.5 | 2.6 | 100 | |
| rT5# | 10 | M | W | 1,400 | NA | 91 | 17 | 1.9 | 100 | |
| rT6 | T13 | 13 | M | AA | 80,000 | NA | 82 | 5 | 12.2 | 100 |
| No. . | Paired3-150 . | Age (yr)3-151 . | Sex . | Race . | WBC†‡ . | %Sρ . | % Blasts3-151 . | RD (mo)3-155 . | DHFR3-154 . | % . |
|---|---|---|---|---|---|---|---|---|---|---|
| rBP1 | BP20 | 8 | M | AA | 17,900 | NA | 95 | 8 | 6.9 | 100 |
| rBP2# | 15 | M | AA | 43,600 | NA | 96 | 9 | 2.4/14.8 | 75/25 | |
| rBP3# | 2 | F | W | 304,800 | NA | 75 | 5 | 1.6 | 100 | |
| rBP4# | 5 | M | W | 4,000 | NA | 90 | 36 | 4.3 | 100 | |
| rBP5# | 3.5 | M | W | 5,900 | NA | 95 | 45 | 2.0/6.9 | 60/40 | |
| rBP6# | BP9 | 4 | F | W | 23,000 | NA | 76 | 24 | 1.0 | 100 |
| rBP79# | 10 | M | W | 3,800 | NA | 80 | 19.5 | 1.5/12.3 | 16/84 | |
| rBP8 | 15.5 | M | W | 4,300 | NA | 70 | 27 | 4.9 | 100 | |
| rT1 | T2 | 14 | F | AA | 163,000 | NA | 61 | 10 | 7.9 | 100 |
| rT2 | T30 | 13.5 | M | W | 176,000 | NA | 80 | 12 | 2.1/19.6 | 22/78 |
| rT3# | 6 | M | W | 79,000 | NA | 90 | 15 | 2.1/15.1 | 59/41 | |
| rT4# | 5 | M | W | 3,800 | NA | 90 | 6.5 | 2.6 | 100 | |
| rT5# | 10 | M | W | 1,400 | NA | 91 | 17 | 1.9 | 100 | |
| rT6 | T13 | 13 | M | AA | 80,000 | NA | 82 | 5 | 12.2 | 100 |
Abbreviations: W, white; AA, African-American; NA, not available.
Paired relapse/diagnostic specimen. Diagnosis specimens are summarized in Tables 1 and 2.
At diagnosis.
Units for WBCs are cells per microliter.
ρ Percentage of S-phase cells, as determined by propidium iodide staining and flow cytometry.
Remission duration intervals (RD) correspond to the time from diagnosis to first relapse.
Relative DHFR contents expressed as a single or multiple subpopulations (A/B/C). Percentage of total blasts in each subpopulation is indicated under column labeled %.
# Patients included in previous study.13