Outcome (Probability ± 95% Confidence Interval) of HLA-Identical Sibling Bone Marrow Transplantations for Severe Aplastic Anemia Between 1976 and 1992
| Outcome . | Year of Transplant . | P* . | ||
|---|---|---|---|---|
| . | 1976-1980 . | 1981-1987 . | 1988-1992 . | . |
| Graft failure (5 yr) | 20% ± 7% | 11% ± 3% | 16% ± 4% | NS |
| Grade II-IV acute GVHD (100 d) | 39% ± 8% | 37% ± 4% | 19% ± 4% | .0001 |
| Chronic GVHD (5 yr) | 37% ± 10% | 47% ± 5% | 32% ± 5% | .001 |
| Interstitial pneumonia (1 yr) | 26% ± 7% | 15% ± 3% | 11% ± 3% | .0002 |
| Survival (5 yr) | 48% ± 7% | 61% ± 4% | 66% ± 6% | .0001 |
| Outcome . | Year of Transplant . | P* . | ||
|---|---|---|---|---|
| . | 1976-1980 . | 1981-1987 . | 1988-1992 . | . |
| Graft failure (5 yr) | 20% ± 7% | 11% ± 3% | 16% ± 4% | NS |
| Grade II-IV acute GVHD (100 d) | 39% ± 8% | 37% ± 4% | 19% ± 4% | .0001 |
| Chronic GVHD (5 yr) | 37% ± 10% | 47% ± 5% | 32% ± 5% | .001 |
| Interstitial pneumonia (1 yr) | 26% ± 7% | 15% ± 3% | 11% ± 3% | .0002 |
| Survival (5 yr) | 48% ± 7% | 61% ± 4% | 66% ± 6% | .0001 |
Log-rank test for trend.