Features of Transplantation Relevant to T-Cell Regeneration
| Patient, Age, Sex, Diagnosis . | Conditioning Regimen . | Donor . | Engraftment (WBC >1.0 G/L) . | GVHD Prophylaxis . | Outcome . |
|---|---|---|---|---|---|
| Thymectomized host | |||||
| 15 yr, M, GS | Cy, Eto, TBI (12 Gy) | Sibling, 17 yr | Day 18 | CSA (12 mo) | Alive, well 24 mo after BMT |
| Thymus-bearing hosts | |||||
| (1) 8 yr, M, ALL relapse | Cy, ATG, TBI (12 Gy) | MUD, 33 yr | Day 20 | CSA (12 mo) | Alive, well 18 mo after BMT |
| (2) 4 yr, F, ALL relapse | Eto, TBI (12 Gy) | Sibling, 16 yr | Day 17 | MTX (3 mo) | Dead of disease 12 mo after BMT |
| (3) 2 yr, M, ALL relapse | ATG, Bu, Cy, Eto | MUD, 28 yr | Day 17 | CSA (6 mo) | Alive, well 18 mo after BMT |
| (4) 35 yr, F, AML | Cy, TBI (12 Gy) | Sibling, 33 yr | Day 15 | CSA (9 mo) | Alive, well 9 mo after BMT |
| (5) 24 hr, M, SAA | ATG, Cy | Sibling, 30 yr | Day 17 | CSA (5 mo) | Alive, well 9 mo after BMT |
| (6) 1.5 yr, F, HLH | ATG, Bu, Cy, Eto | MUD, 33 yr | Day 13 | CSA (6 mo) | Alive, well 15 mo after BMT |
| (7) 5 yr, F, ALL relapse | Eto, TBI (12 Gy) | Syngeneic, 5 yr | Day 19 | CSA (6 mo) | Alive, well 9 mo after BMT |
| (8) 24 yr, M, SAA | ATG, Cy | Sibling, 14 yr | Day 17 | CSA (18 mo) | Alive, well 24 mo after BMT |
| (9) 35 yr, F, CML | Cy, TBI (12 Gy) | Sibling, 30 yr | Day 23 | CSA (12 mo) | Alive, well 14 mo after BMT |
| Patient, Age, Sex, Diagnosis . | Conditioning Regimen . | Donor . | Engraftment (WBC >1.0 G/L) . | GVHD Prophylaxis . | Outcome . |
|---|---|---|---|---|---|
| Thymectomized host | |||||
| 15 yr, M, GS | Cy, Eto, TBI (12 Gy) | Sibling, 17 yr | Day 18 | CSA (12 mo) | Alive, well 24 mo after BMT |
| Thymus-bearing hosts | |||||
| (1) 8 yr, M, ALL relapse | Cy, ATG, TBI (12 Gy) | MUD, 33 yr | Day 20 | CSA (12 mo) | Alive, well 18 mo after BMT |
| (2) 4 yr, F, ALL relapse | Eto, TBI (12 Gy) | Sibling, 16 yr | Day 17 | MTX (3 mo) | Dead of disease 12 mo after BMT |
| (3) 2 yr, M, ALL relapse | ATG, Bu, Cy, Eto | MUD, 28 yr | Day 17 | CSA (6 mo) | Alive, well 18 mo after BMT |
| (4) 35 yr, F, AML | Cy, TBI (12 Gy) | Sibling, 33 yr | Day 15 | CSA (9 mo) | Alive, well 9 mo after BMT |
| (5) 24 hr, M, SAA | ATG, Cy | Sibling, 30 yr | Day 17 | CSA (5 mo) | Alive, well 9 mo after BMT |
| (6) 1.5 yr, F, HLH | ATG, Bu, Cy, Eto | MUD, 33 yr | Day 13 | CSA (6 mo) | Alive, well 15 mo after BMT |
| (7) 5 yr, F, ALL relapse | Eto, TBI (12 Gy) | Syngeneic, 5 yr | Day 19 | CSA (6 mo) | Alive, well 9 mo after BMT |
| (8) 24 yr, M, SAA | ATG, Cy | Sibling, 14 yr | Day 17 | CSA (18 mo) | Alive, well 24 mo after BMT |
| (9) 35 yr, F, CML | Cy, TBI (12 Gy) | Sibling, 30 yr | Day 23 | CSA (12 mo) | Alive, well 14 mo after BMT |
Abbreviations: GS, granulocytic sarcoma; ALL, acute lymphoblastic leukemia; AML, acute myelogenous leukemia; SAA, severe aplastic anemia; HLH, hemophagocytic lymphohistiocytosis; CML, chronic myelogenous leukemia; Cy, cyclophosphamide; Eto, etoposide; TBI, total body irradiation; MTX, methotrexate; ATG, antithymocyte globuline; Bu, busulphane; MUD, matched unrelated donor.