Table 3. Relative Repopulating Abilities... | American Society of Hematology

Table 3.

Relative Repopulating Abilities of Late Fetal and Newborn Blood, Liver, and Spleen Cells

Time (d)	Amount Donor	Late Fetal:			Newborn			Control BM
		Blood	Liver	Spleen	Blood	Liver	Spleen
21	P_P	17 ± 12	41 ± 15	39 ± 7	24 ± 10	31 ± 1	51 ± 1	64 ± 5
	RU_P*	0.8	28	6.4	1.3	26	10	18
	P_L	32 ± 20	47 ± 7	37 ± 13	30 ± 16	45 ± 12	55 ± 11	71 ± 6
	RU_L	1.9	35	5.9	1.7	33	12	24
	P_G	38 ± 21	62 ± 16	51 ± 10	35 ± 15	71	74 ± 2	73 ± 6
	RU_G	2.5	65	10	2.2	98	28	27
118	P_E	37 ± 39	56 ± 4	63 ± 4	65 ± 26	57 ± 5	72 ± 5	72 ± 33
	RU_E	2.3	51	17	7.4	53	26	26
	P_L	40 ± 28	48 ± 3	50 ± 4	53 ± 24	52 ± 5	57 ± 3	61 ± 21
	RU_L	2.7	37	10	4.5	43	13	16
245	P_E	46 ± 40	68 ± 9	67 ± 7	70 ± 32	68 ± 8	74 ± 5	72 ± 35
	RU_E	3.4	85	20	9.3	85	25	26
	P_L	37 ± 36	56 ± 10	51 ± 12	59 ± 34	58 ± 8	67 ± 4	66 ± 33
	RU_L	2.3	51	10	5.8	55	20	19
413	P_E	49 ± 42	68 ± 9	— ^3-151	75 ± 33	75 ± 5	80 ± 6	60 ± 47
	RU_E	3.8	85	—	12	120	40	15
	P_L	38 ± 39	54 ± 13	—	53 ± 30	62 ± 4	61 ± 12	54 ± 39
	RU_L	2.5	47	—	4.1	65	16	12

Time (d)	Amount Donor	Late Fetal:			Newborn			Control BM
		Blood	Liver	Spleen	Blood	Liver	Spleen
21	P_P	17 ± 12	41 ± 15	39 ± 7	24 ± 10	31 ± 1	51 ± 1	64 ± 5
	RU_P*	0.8	28	6.4	1.3	26	10	18
	P_L	32 ± 20	47 ± 7	37 ± 13	30 ± 16	45 ± 12	55 ± 11	71 ± 6
	RU_L	1.9	35	5.9	1.7	33	12	24
	P_G	38 ± 21	62 ± 16	51 ± 10	35 ± 15	71	74 ± 2	73 ± 6
	RU_G	2.5	65	10	2.2	98	28	27
118	P_E	37 ± 39	56 ± 4	63 ± 4	65 ± 26	57 ± 5	72 ± 5	72 ± 33
	RU_E	2.3	51	17	7.4	53	26	26
	P_L	40 ± 28	48 ± 3	50 ± 4	53 ± 24	52 ± 5	57 ± 3	61 ± 21
	RU_L	2.7	37	10	4.5	43	13	16
245	P_E	46 ± 40	68 ± 9	67 ± 7	70 ± 32	68 ± 8	74 ± 5	72 ± 35
	RU_E	3.4	85	20	9.3	85	25	26
	P_L	37 ± 36	56 ± 10	51 ± 12	59 ± 34	58 ± 8	67 ± 4	66 ± 33
	RU_L	2.3	51	10	5.8	55	20	19
413	P_E	49 ± 42	68 ± 9	— ^3-151	75 ± 33	75 ± 5	80 ± 6	60 ± 47
	RU_E	3.8	85	—	12	120	40	15
	P_L	38 ± 39	54 ± 13	—	53 ± 30	62 ± 4	61 ± 12	54 ± 39
	RU_L	2.5	47	—	4.1	65	16	12

In experiment 2, percentages of donor type platelets, lymphocytes or granulocytes (P_P, P_L, or P_G); or erythrocytes and lymphocytes (P_E, P_L) are given as mean ± SD; n = 13 to 20 recipients per group with fetal or newborn blood, or control BM and 3 to 4 in other groups, except 2 to 4 at 413 days. Recipients were given the following doses: Blood, 2 × 10⁵ B6 standard BM cels, mixed with 5 × 10⁵ B6-Hbb^dGpi 1^a donor nucleated blood cells from 19 day fetal or newborn mice; Liver, 4 × 10⁶ B6 standard BM cells, mixed with 1 × 10⁶ B6-Hbb^dGpi 1^a donor 19 day fetal or newborn liver cells; Spleen, equal numbers of B6 standard BM, mixed with B6-Hbb^dGpi 1^a donor cells, 1.52 × 10⁶ with late fetal or 1.8 × 10⁶ with newborn spleen cells; Controls, 2 × 10⁶ donor and standard adult BM cells.

F3-150

RU per 10⁶ donor cells injected, as in Table 1. In addition, recipients of 2 or 7.6 × 10⁶ B6-Hbb^dGpi 1^d nucleated blood cells from adults, plus 2 × 10⁵ standard BM cells, had donor percentages averaging 20 to 29, so RU per 10⁶ averaged 0.01 to 0.03 with n = 2 to 4.

F3-151

All recipients died.

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