Generation and Expansion of Autologous Antileukemia T-Cell Lines From the Bone Marrow of Patients With Pre-B–Cell Leukemias (Pre-B ALL and Pre-B CML)
Patient . | Day 0 (T-cell number) . | Day 30 (T-cell number) . | T-Cell Expansion . | |||
---|---|---|---|---|---|---|
. | CD4+ . | CD8+ . | CD4+ . | CD8+ . | (fold increase) . | |
. | . | . | . | . | CD4+ . | CD8+ . |
ALL-17 | 0.8 × 106 | 0.7 × 106 | 18 × 106 | 49 × 106 | 22.5 | 70.0 |
ALL-20 | 0.9 × 106 | 1.2 × 106 | 26 × 106 | 82 × 106 | 28.9 | 68.3 |
ALL-21 | 1.1 × 106 | 0.6 × 106 | 22 × 106 | 50 × 106 | 19.6 | 84.0 |
ALL-25 | 1.3 × 106 | 0.7 × 106 | 11 × 106 | 18 × 106 | 8.2 | 26.1 |
ALL-28 | 1.1 × 106 | 0.9 × 106 | 33 × 106 | 66 × 106 | 29.9 | 73.3 |
ALL-30 | 1.3 × 106 | 1.9 × 106 | 0 | 0 | 0 | 0 |
ALL-31 | 2.7 × 106 | 1.8 × 106 | 19 × 106 | 28 × 106 | 7.1 | 15.8 |
ALL-33 | 1.5 × 106 | 1.7 × 106 | 17 × 106 | 51 × 106 | 11.0 | 30.0 |
ALL-36 | 2.0 × 106 | 1.3 × 106 | 0 | 0 | 0 | 0 |
ALL-38 | 0.6 × 106 | 1.2 × 106 | 0 | 0 | 0 | 0 |
ALL-39 | 0.8 × 106 | 1.0 × 106 | 0 | 0 | 0 | 0 |
ALL-41 | 0.9 × 106 | 1.0 × 106 | 11 × 106 | 49 × 106 | 12.1 | 48.8 |
CML-1 | 0.4 × 106 | 1.1 × 106 | 2.8 × 106 | 6.3 × 106 | 7.0 | 5.7 |
CML-2 | 1.3 × 106 | 1.0 × 106 | 16 × 106 | 26 × 106 | 12.2 | 26.4 |
CML-3 | 0.9 × 106 | 0.7 × 106 | 0 | 0 | 0 | 0 |
Patient . | Day 0 (T-cell number) . | Day 30 (T-cell number) . | T-Cell Expansion . | |||
---|---|---|---|---|---|---|
. | CD4+ . | CD8+ . | CD4+ . | CD8+ . | (fold increase) . | |
. | . | . | . | . | CD4+ . | CD8+ . |
ALL-17 | 0.8 × 106 | 0.7 × 106 | 18 × 106 | 49 × 106 | 22.5 | 70.0 |
ALL-20 | 0.9 × 106 | 1.2 × 106 | 26 × 106 | 82 × 106 | 28.9 | 68.3 |
ALL-21 | 1.1 × 106 | 0.6 × 106 | 22 × 106 | 50 × 106 | 19.6 | 84.0 |
ALL-25 | 1.3 × 106 | 0.7 × 106 | 11 × 106 | 18 × 106 | 8.2 | 26.1 |
ALL-28 | 1.1 × 106 | 0.9 × 106 | 33 × 106 | 66 × 106 | 29.9 | 73.3 |
ALL-30 | 1.3 × 106 | 1.9 × 106 | 0 | 0 | 0 | 0 |
ALL-31 | 2.7 × 106 | 1.8 × 106 | 19 × 106 | 28 × 106 | 7.1 | 15.8 |
ALL-33 | 1.5 × 106 | 1.7 × 106 | 17 × 106 | 51 × 106 | 11.0 | 30.0 |
ALL-36 | 2.0 × 106 | 1.3 × 106 | 0 | 0 | 0 | 0 |
ALL-38 | 0.6 × 106 | 1.2 × 106 | 0 | 0 | 0 | 0 |
ALL-39 | 0.8 × 106 | 1.0 × 106 | 0 | 0 | 0 | 0 |
ALL-41 | 0.9 × 106 | 1.0 × 106 | 11 × 106 | 49 × 106 | 12.1 | 48.8 |
CML-1 | 0.4 × 106 | 1.1 × 106 | 2.8 × 106 | 6.3 × 106 | 7.0 | 5.7 |
CML-2 | 1.3 × 106 | 1.0 × 106 | 16 × 106 | 26 × 106 | 12.2 | 26.4 |
CML-3 | 0.9 × 106 | 0.7 × 106 | 0 | 0 | 0 | 0 |