Effect of KB-R7785 on GVHD-Associated Lymphoid Hypoplasia
| Mice . | Cell No. (×107) . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | H-2Kd+Kb+ . | H-2Kd−Kb+ . | . | . | . | . | ||||
| . | CD4+ . | CD8+ . | B220+ . | CD4+ . | CD8+ . | B220+ . | . | . | . | . |
| Normal | 2.4 ± 0.7 | 1.3 ± 0.1 | 7.0 ± 0.1 | — | — | — | ||||
| GVHD | 1.1 ± 0.1 | 1.0 ± 0.1 | 1.4 ± 0.5 | 1.1 ± 0.5 | 1.0 ± 0.1 | 0.5 ± 0.2 | ||||
| KB-R7785 | 4.4 ± 1.3 | 4.2 ± 1.0 | 7.3 ± 1.4 | 3.8 ± 0.6 | 4.8 ± 1.3 | 6.0 ± 1.2 | ||||
| Mice . | Cell No. (×107) . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | H-2Kd+Kb+ . | H-2Kd−Kb+ . | . | . | . | . | ||||
| . | CD4+ . | CD8+ . | B220+ . | CD4+ . | CD8+ . | B220+ . | . | . | . | . |
| Normal | 2.4 ± 0.7 | 1.3 ± 0.1 | 7.0 ± 0.1 | — | — | — | ||||
| GVHD | 1.1 ± 0.1 | 1.0 ± 0.1 | 1.4 ± 0.5 | 1.1 ± 0.5 | 1.0 ± 0.1 | 0.5 ± 0.2 | ||||
| KB-R7785 | 4.4 ± 1.3 | 4.2 ± 1.0 | 7.3 ± 1.4 | 3.8 ± 0.6 | 4.8 ± 1.3 | 6.0 ± 1.2 | ||||
Cell numbers of CD4+ T, CD8+ T, and B220+ B cells of host (H-2Kd+Kb+) or donor (H-2Kd−Kb+) origin in splenocytes from normal CBF1, GVHD, or KB-R7785–treated mice on day 14 were calculated from the total numbers of splenocytes recovered and the percentages of each subpopulation were determined by three-color flow cytometric analysis. Data represent the mean ± SD of 3 mice in each group.