Sensitivity of Colon and Leukemia Lines to Recombinant Immunotoxins Binding to the Human Transferrin Receptor
| Cell Line . | Cell Type . | IC50 (ng/mL) ± SD . | |
|---|---|---|---|
| . | . | Anti-TFR(Fv)–PE38KDEL . | DT388–Anti-TFR(Fv) . |
| LS174T | Colon | 0.008 ± 0.003 | 0.4 ± 0.05 |
| SW403 | Colon | 0.02 ± 0.007 | 0.7 ± 0.3 |
| N87 | Gastric | 0.003 ± 0.0004 | 0.2 ± 0.07 |
| HTB-103 | Gastric | 0.002 ± 0.0006 | 0.2 ± 0.06 |
| HL60 | Promyelocytic | 0.4 ± 0.15 | 0.2 ± 0.015 |
| TF-1 | Erythroleukemia | 0.018 ± 0.006 | 0.13 ± 0.1 |
| U937 | Monocytic | 0.1 ± 0.09 | 0.13 ± 0.08 |
| Cell Line . | Cell Type . | IC50 (ng/mL) ± SD . | |
|---|---|---|---|
| . | . | Anti-TFR(Fv)–PE38KDEL . | DT388–Anti-TFR(Fv) . |
| LS174T | Colon | 0.008 ± 0.003 | 0.4 ± 0.05 |
| SW403 | Colon | 0.02 ± 0.007 | 0.7 ± 0.3 |
| N87 | Gastric | 0.003 ± 0.0004 | 0.2 ± 0.07 |
| HTB-103 | Gastric | 0.002 ± 0.0006 | 0.2 ± 0.06 |
| HL60 | Promyelocytic | 0.4 ± 0.15 | 0.2 ± 0.015 |
| TF-1 | Erythroleukemia | 0.018 ± 0.006 | 0.13 ± 0.1 |
| U937 | Monocytic | 0.1 ± 0.09 | 0.13 ± 0.08 |