Clinical and Pathological Features of B-Cell NHLs in HCV-Positive Versus HCV-Negative Patients at Onset
| . | HCV-Positive (n = 35) . | HCV-Negative (n = 122)* . |
|---|---|---|
| Patient sex (F:M) | 20:15 | 59:63 |
| Patient mean age ± SD (range) | 64.6 ± 10.2 (27-79) | 56.5 ± 14.5 (21-86) |
| NHL stage | ||
| I/II/III/IV | 9/1/4/21 | 23/24/14/61 |
| A/B | 27/8 | 93/29 |
| NHL localization | ||
| Primary extranodal | 23/35 | 23/122 (P < .001) |
| liver | 4 | 0 (P = .002) |
| spleen | 3 | 0 (P = .01) |
| salivary glands | 4 | 1 (P = .009) |
| Other sites: | ||
| rhinofarinx/tonsil/tongue | 1/1/0 | 2/0/1 |
| stomach/small intestine | 4/1 | 7/0 |
| skin/lung/kidney/breast/bone | 3/2/0/1/0 | 6/2/2/0/1 |
| brain or cerebrospinal fluid | 2 | 3 |
| Nodal + extranodal | 6/35 | 39/122 |
| Only nodal | 6/35 | 60/122 (P = .001) |
| Bone marrow involvement | 13/35 | 42/122 |
| NHL histotype (REAL classification) | ||
| Lymphoplasmocytoid/immunocytoma | 2 | 3 |
| Mantle cell | 1 | 10 |
| Follicular center, follicular | 1 | 26 (P = .01) |
| Extranodal marginal zone (MALT) | 5 | 12 |
| Nodal marginal zone | 0 | 2 |
| Diffuse large cell | 23 | 60 |
| Burkitt's | 1 | 1 |
| Provisional entities | ||
| Burkitt's like | 0 | 4 |
| Splenic marginal zone | 0 | 1 |
| Follicular center, diffuse, small cell | 0 | 1 |
| Unclassifiable | 2 | 2 |
| . | HCV-Positive (n = 35) . | HCV-Negative (n = 122)* . |
|---|---|---|
| Patient sex (F:M) | 20:15 | 59:63 |
| Patient mean age ± SD (range) | 64.6 ± 10.2 (27-79) | 56.5 ± 14.5 (21-86) |
| NHL stage | ||
| I/II/III/IV | 9/1/4/21 | 23/24/14/61 |
| A/B | 27/8 | 93/29 |
| NHL localization | ||
| Primary extranodal | 23/35 | 23/122 (P < .001) |
| liver | 4 | 0 (P = .002) |
| spleen | 3 | 0 (P = .01) |
| salivary glands | 4 | 1 (P = .009) |
| Other sites: | ||
| rhinofarinx/tonsil/tongue | 1/1/0 | 2/0/1 |
| stomach/small intestine | 4/1 | 7/0 |
| skin/lung/kidney/breast/bone | 3/2/0/1/0 | 6/2/2/0/1 |
| brain or cerebrospinal fluid | 2 | 3 |
| Nodal + extranodal | 6/35 | 39/122 |
| Only nodal | 6/35 | 60/122 (P = .001) |
| Bone marrow involvement | 13/35 | 42/122 |
| NHL histotype (REAL classification) | ||
| Lymphoplasmocytoid/immunocytoma | 2 | 3 |
| Mantle cell | 1 | 10 |
| Follicular center, follicular | 1 | 26 (P = .01) |
| Extranodal marginal zone (MALT) | 5 | 12 |
| Nodal marginal zone | 0 | 2 |
| Diffuse large cell | 23 | 60 |
| Burkitt's | 1 | 1 |
| Provisional entities | ||
| Burkitt's like | 0 | 4 |
| Splenic marginal zone | 0 | 1 |
| Follicular center, diffuse, small cell | 0 | 1 |
| Unclassifiable | 2 | 2 |
When not reported, no significant differences were detected.