Clinical and Laboratory Characteristics of Seven Patients With Sickle Cell Disease Treated With Valproic Acid
| Parameter . | Pre-Valproic Acid . | Post-Valproic Acid . | P Value . |
|---|---|---|---|
| Hemoglobin (g/dL) | 8.3 ± 0.9 | 9.3 ± 1.2 | .05 |
| Hemoglobin F (%) | 6.4 ± 2.6 | 8.4 ± 4.3 | .05 |
| Hemoglobin F (g/dL) | 5.4 ± 2.2 | 7.9 ± 4.5 | .05 |
| Mean cell volume (fL) | 83 ± 8.0 | 86 ± 7.0 | NS |
| Annual rate of | |||
| Vaso-occlusive crises | 3.1 ± 3.1 | 5.8 ± 9.0 | NS |
| Blood transfusions | 1.1 ± 3.0 | 0.3 ± 0.7 | NS |
| In-patient hospital days | 31 ± 28 | 37 ± 53 | NS |
| Parameter . | Pre-Valproic Acid . | Post-Valproic Acid . | P Value . |
|---|---|---|---|
| Hemoglobin (g/dL) | 8.3 ± 0.9 | 9.3 ± 1.2 | .05 |
| Hemoglobin F (%) | 6.4 ± 2.6 | 8.4 ± 4.3 | .05 |
| Hemoglobin F (g/dL) | 5.4 ± 2.2 | 7.9 ± 4.5 | .05 |
| Mean cell volume (fL) | 83 ± 8.0 | 86 ± 7.0 | NS |
| Annual rate of | |||
| Vaso-occlusive crises | 3.1 ± 3.1 | 5.8 ± 9.0 | NS |
| Blood transfusions | 1.1 ± 3.0 | 0.3 ± 0.7 | NS |
| In-patient hospital days | 31 ± 28 | 37 ± 53 | NS |
Data obtained at evaluation before beginning valproic acid were compared with those at the completion of the study using the Student's t-test for paired data. All tests were two-tailed; a significance level of .05 was used to indicate statistical significance.