Table 1. Bleeding Episodes in... | American Society of Hematology

Table 1.

Bleeding Episodes in Individuals With Homozygous PAI-1 Deficiency

Individual	Gender	Age	Family	Bleeding Episodes
1	Female	15 y	1	Life-threatening postoperative hemorrhage requiring transfusion. Large palatal hemorrhage requiring hospitalization and transfusion. Protracted menstrual bleeding resulting in anemia.
(Proband)
2	Male	4 mo	1	Large epidural hematoma requiring surgical drainage after minor head trauma.
3	Female	14 y	2	Large subperiosteal mandibular bleed after striking jaw. Subcutaneous hematomas after minimal trauma. Excessive bruising.
4	Male	13 y	2	Elbow and knee hemarthroses after minor trauma. Delayed bleeding after repair of inguinal hernia.
5	Female	11 y	2	Frequent bruising.
6	Female	5 y	2	Knee hemarthroses.
7	Female	2 y	2	Frequent bruising.

Individual	Gender	Age	Family	Bleeding Episodes
1	Female	15 y	1	Life-threatening postoperative hemorrhage requiring transfusion. Large palatal hemorrhage requiring hospitalization and transfusion. Protracted menstrual bleeding resulting in anemia.
(Proband)
2	Male	4 mo	1	Large epidural hematoma requiring surgical drainage after minor head trauma.
3	Female	14 y	2	Large subperiosteal mandibular bleed after striking jaw. Subcutaneous hematomas after minimal trauma. Excessive bruising.
4	Male	13 y	2	Elbow and knee hemarthroses after minor trauma. Delayed bleeding after repair of inguinal hernia.
5	Female	11 y	2	Frequent bruising.
6	Female	5 y	2	Knee hemarthroses.
7	Female	2 y	2	Frequent bruising.

A total of three life-threatening bleeds (in individuals 1 and 2) were observed during 60 patient-years of observation. Family 1 contains the proband, as shown in Fig 1. Family 2 is the family shown in Fig 2.

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