Tumor Formation in RAR α Antisense Mice
| Case . | Line . | Sex . | Genotype . | Age (mo) . | Tumor (lineage) . | Site . |
|---|---|---|---|---|---|---|
| 1 | 1 | M | Homozygous | 2 | Lymphoma (ND) | Thymus |
| 2 | 1 | F | Homozygous | 3 | Lymphoma (T cell) | Thymus |
| 3 | 3 | M | Homozygous | 6 | Lymphoma (ND) | Eye |
| 4 | 2 | M | Homozygous | 7 | Lymphoma (B cell) | Abdomen |
| 5 | 1 | F | Homozygous | 5 | Lymphoma (T cell) | Thymus |
| 6 | 3 | M | Homozygous | 7 | Lymphoma (ND) | Abdomen |
| 7 | 2 | F | Homozygous | 9 | Lymphoma (B cell) | Abdomen |
| 8 | 1 | F | Homozygous | 8 | Lymphoma (ND) | Abdomen |
| 9 | 1 | M | Homozygous | 6 | Lymphoma (ND) | Axillary |
| 10 | 2 | F | Homozygous | 10 | Lymphoma (B cell) | Abdomen |
| 11 | 2 | F | Homozygous | 4 | Lymphoma (ND) | Abdomen |
| Carcinoid | Lung | |||||
| 12 | 2 | M | Homozygous | 4 | Lymphoma (ND) | Abdomen |
| 13 | 1 × 2 | F | Homozygous | 4 | Lymphoma (B cell) | Abdomen |
| 14 | 1 | F | Homozygous | 10 | Sweat gland | Axillary |
| 15 | 1 × 2 | F | Homozygous | 4 | Lymphoma (B cell) | Abdomen |
| 16 | 3 | M | Homozygous | 12 | Lymphoma (ND) | Abdomen |
| 17 | 1 | F | Homozygous | 16 | Sweat gland | Axillary |
| 18 | 1 | F | Hemizygous* | 18 | Lymphoma (B cell) | Abdomen |
| 19 | 2 | M | Hemizygous* | 18 | Lymphoma (ND) | Abdomen |
| Case . | Line . | Sex . | Genotype . | Age (mo) . | Tumor (lineage) . | Site . |
|---|---|---|---|---|---|---|
| 1 | 1 | M | Homozygous | 2 | Lymphoma (ND) | Thymus |
| 2 | 1 | F | Homozygous | 3 | Lymphoma (T cell) | Thymus |
| 3 | 3 | M | Homozygous | 6 | Lymphoma (ND) | Eye |
| 4 | 2 | M | Homozygous | 7 | Lymphoma (B cell) | Abdomen |
| 5 | 1 | F | Homozygous | 5 | Lymphoma (T cell) | Thymus |
| 6 | 3 | M | Homozygous | 7 | Lymphoma (ND) | Abdomen |
| 7 | 2 | F | Homozygous | 9 | Lymphoma (B cell) | Abdomen |
| 8 | 1 | F | Homozygous | 8 | Lymphoma (ND) | Abdomen |
| 9 | 1 | M | Homozygous | 6 | Lymphoma (ND) | Axillary |
| 10 | 2 | F | Homozygous | 10 | Lymphoma (B cell) | Abdomen |
| 11 | 2 | F | Homozygous | 4 | Lymphoma (ND) | Abdomen |
| Carcinoid | Lung | |||||
| 12 | 2 | M | Homozygous | 4 | Lymphoma (ND) | Abdomen |
| 13 | 1 × 2 | F | Homozygous | 4 | Lymphoma (B cell) | Abdomen |
| 14 | 1 | F | Homozygous | 10 | Sweat gland | Axillary |
| 15 | 1 × 2 | F | Homozygous | 4 | Lymphoma (B cell) | Abdomen |
| 16 | 3 | M | Homozygous | 12 | Lymphoma (ND) | Abdomen |
| 17 | 1 | F | Homozygous | 16 | Sweat gland | Axillary |
| 18 | 1 | F | Hemizygous* | 18 | Lymphoma (B cell) | Abdomen |
| 19 | 2 | M | Hemizygous* | 18 | Lymphoma (ND) | Abdomen |
We generated 42 homozygous (17, line 1; 13, line 2; 8, line 3, and 4, crossing 1 × 2) transgenic mice. Eight died at 2 to 4 months of age (4, line 1; 2, line 2; 1 line 3, and 1, crossing 1 × 2). Of the remaining 34, 15 (44%) developed lymphomas and two developed sweat gland tumors.
Abbreviation: ND, not determined.
Only 2 of 86 hemizygous mice developed lymphomas.