Table 1. Effects of PF4 on the IC 50 of... | American Society of Hematology

Table 1.

Effects of PF4 on the IC₅₀ of Cytotoxic Drugs In Vitro

Drug	IC₅₀ ( μg/mL)
	Without PF4	With PF4
DNR	0.01 ± 0.002	2.20 ± 0.15^*
ETP	0.15 ± 0.001	2.78 ± 0.11^*
Adriamycin	0.11 ± 0.004	2.10 ± 0.09^*
Methotrexate	0.09 ± 0.01	1.90 ± 0.12^*
5-FU	2.50 ± 0.45	5.60 ± 0.50^*
Vincristine	0.58 ± 0.03	1.76 ± 0.50^*

Drug	IC₅₀ ( μg/mL)
	Without PF4	With PF4
DNR	0.01 ± 0.002	2.20 ± 0.15^*
ETP	0.15 ± 0.001	2.78 ± 0.11^*
Adriamycin	0.11 ± 0.004	2.10 ± 0.09^*
Methotrexate	0.09 ± 0.01	1.90 ± 0.12^*
5-FU	2.50 ± 0.45	5.60 ± 0.50^*
Vincristine	0.58 ± 0.03	1.76 ± 0.50^*

Normal human bone marrow cells were incubated with PF4 (5 μg/mL) for 48 hours. Cytotoxic drugs at concentrations of 0.1, 1, 5, 10, 20, 50, 100, 250, and 500 ng/mL and 1, 2.5, 5, and 10 μg/mL were respectively added to the wells and the cells were further cultured for an additional 24 hours. Cell chemosensitivity was measured by an MTT assay. Data are expressed as the mean ± SEM from triplicate determinations of 3 separate experiments.

P < .01 v control cells without PF4, as determined by Student's t-test.

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