Table 2.

Therapy Response and Survival of 182 Patients With Ann Arbor Stage II-IV High-Grade Malignant B-Cell Lymphomas of the Kiel Classification1,2 Treated by the COP-BLAM/IMVP-16 Regimen5 

CBB-IBB-ALC
n (%)n (%)n (%)
Total n 127 (70) 33 (18) 22 (12) 
Complete remission rate* 
Total 
by cycle no. 72 (57) 14 (42) 10 (45) 
Rapid   3 60 (47) 12 (36) 5 (23) 
Rapid and maintained 3 → 7 52 (41) 9 (27) 4 (18) 
Delayed    → 7 21 (17) 5 (15) 6 (27) 
Early relapse 3 → 7 6 (5) 3 (9) 1 (5) 
Total relapse rate 21 (29) 10 (70) 3 (30) 
Median survival 
Overall (not reached) 16 mo 20 mo 
Relapse-free (not reached) 8 mo (not reached) 
CBB-IBB-ALC
n (%)n (%)n (%)
Total n 127 (70) 33 (18) 22 (12) 
Complete remission rate* 
Total 
by cycle no. 72 (57) 14 (42) 10 (45) 
Rapid   3 60 (47) 12 (36) 5 (23) 
Rapid and maintained 3 → 7 52 (41) 9 (27) 4 (18) 
Delayed    → 7 21 (17) 5 (15) 6 (27) 
Early relapse 3 → 7 6 (5) 3 (9) 1 (5) 
Total relapse rate 21 (29) 10 (70) 3 (30) 
Median survival 
Overall (not reached) 16 mo 20 mo 
Relapse-free (not reached) 8 mo (not reached) 

Lymphoma subtypes: CB, centroblastic; B-IB, B-immunoblastic; B-ALC, B-anaplastic large cell (CD30+).

*

P = .26.

P = .010 (Chi square test).

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