Case Series of NHLs (47 cases, p53-positive group and 23 cases, p53-negative control group) Subdivided According to the Working Formulation Categories, Immunohistochemical Expression of p53 and p21 Proteins
| Working Formulation . | No. of Tested Cases . | p53+ p21+ . | p53+ p21− . | p53− p21+ . | p53− p21− . |
|---|---|---|---|---|---|
| Low-grade | |||||
| Small lymphocytic | 4 | 1 | 3 | — | — |
| Follicular predominantly small cleaved cell | 6 | — | — | — | 6 |
| Follicular, mixed, small cleaved and large cell | 3 | — | 2 | — | 1 |
| Intermediate-grade | |||||
| Follicular, predominantly large cell | 1 | — | — | — | 1 |
| Diffuse mixed, small and large cell | 2 | 1 | — | — | 1 |
| Diffuse, large cell | 24 | 7 | 11 | — | 6 |
| High-grade | |||||
| Large cell, immunoblastic | 8 | 3 | 5 | — | — |
| Small noncleaved | 9 | 2 | 7 | — | — |
| Miscellaneous | |||||
| Anaplastic large cell (Ki-1+) | 6 | 1 | 3 | 2 | — |
| Intestinal T cell | 1 | 1 | — | — | — |
| MALT-type | 5 | — | — | — | 5 |
| Monocytoid | 1 | — | — | 1 | — |
| Total | 70 | 16 | 31 | 3 | 20 |
| Working Formulation . | No. of Tested Cases . | p53+ p21+ . | p53+ p21− . | p53− p21+ . | p53− p21− . |
|---|---|---|---|---|---|
| Low-grade | |||||
| Small lymphocytic | 4 | 1 | 3 | — | — |
| Follicular predominantly small cleaved cell | 6 | — | — | — | 6 |
| Follicular, mixed, small cleaved and large cell | 3 | — | 2 | — | 1 |
| Intermediate-grade | |||||
| Follicular, predominantly large cell | 1 | — | — | — | 1 |
| Diffuse mixed, small and large cell | 2 | 1 | — | — | 1 |
| Diffuse, large cell | 24 | 7 | 11 | — | 6 |
| High-grade | |||||
| Large cell, immunoblastic | 8 | 3 | 5 | — | — |
| Small noncleaved | 9 | 2 | 7 | — | — |
| Miscellaneous | |||||
| Anaplastic large cell (Ki-1+) | 6 | 1 | 3 | 2 | — |
| Intestinal T cell | 1 | 1 | — | — | — |
| MALT-type | 5 | — | — | — | 5 |
| Monocytoid | 1 | — | — | 1 | — |
| Total | 70 | 16 | 31 | 3 | 20 |
Abbreviation: MALT, mucosa-associated lymphoma tissue.