Table 1. Uptake Kinetics of MTX and... | American Society of Hematology

Table 1.

Uptake Kinetics of MTX and 5-Methyl THF

		WT MOLT-3	MOLT-3/MTX₂₀₀	MOLT-3/MTX_10,000
Methotrexate	Vmax	6.9	1.7	1.1
	Kt	9.1	10.7	8.8
5-methyl THF	Vmax	5.6	3.0	2.7
	Kt	5.2	4.2	4.3

		WT MOLT-3	MOLT-3/MTX₂₀₀	MOLT-3/MTX_10,000
Methotrexate	Vmax	6.9	1.7	1.1
	Kt	9.1	10.7	8.8
5-methyl THF	Vmax	5.6	3.0	2.7
	Kt	5.2	4.2	4.3

Vmax is expressed as nmol MTX or 5-methyl THF uptake/2.5 min/10⁷ cells. Kt is expressed as μmol/L.