Pharmacokinetic Parameters of RFT5-SMPT-dgA
| Patient No. . | Dose (mg/m2) . | Cmax (μg/mL) . | T1/2max (h) . | AUC (mg × h/L)max . | Cl (mL/h)max . |
|---|---|---|---|---|---|
| 1 | 5 | 0.78 | 4.54 | 3.16 | 4,700 |
| 2 | 5 | 5.49 | 4.04 | 19.66 | 410 |
| 3 | 5 | 0.20 | 4.05 | 1.12 | 9,386 |
| 4 | 10 | 1.23 | 4.72 | 1.49 | 5,853 |
| 5 | 10 | 7.81 | 9.73 | 132.98 | 60 |
| 6 | 10 | 7.00 | 6.57 | 112.93 | 90 |
| 7 | 15 | 7.94 | 7.83 | 44.19 | 302 |
| 8 | 15 | 3.65 | 7.16 | 33.46 | 452 |
| 9 | 15 | 7.44 | 3.98 | 57.30 | 391 |
| 10 | 15 | 2.12 | 3.97 | 16.78 | 917 |
| 11 | 15 | 6.27 | 10.53 | 89.02 | 136 |
| 12 | 15 | 6.91 | 4.9 | 76.19 | 226 |
| 13 | 20 | 9.70 | 5.3 | 68.51 | 522 |
| 14 | 20 | 9.57 | 8.41 | 95.36 | 81 |
| 15 | 20 | 8.80 | 5.52 | 80.93 | 235 |
| Patient No. . | Dose (mg/m2) . | Cmax (μg/mL) . | T1/2max (h) . | AUC (mg × h/L)max . | Cl (mL/h)max . |
|---|---|---|---|---|---|
| 1 | 5 | 0.78 | 4.54 | 3.16 | 4,700 |
| 2 | 5 | 5.49 | 4.04 | 19.66 | 410 |
| 3 | 5 | 0.20 | 4.05 | 1.12 | 9,386 |
| 4 | 10 | 1.23 | 4.72 | 1.49 | 5,853 |
| 5 | 10 | 7.81 | 9.73 | 132.98 | 60 |
| 6 | 10 | 7.00 | 6.57 | 112.93 | 90 |
| 7 | 15 | 7.94 | 7.83 | 44.19 | 302 |
| 8 | 15 | 3.65 | 7.16 | 33.46 | 452 |
| 9 | 15 | 7.44 | 3.98 | 57.30 | 391 |
| 10 | 15 | 2.12 | 3.97 | 16.78 | 917 |
| 11 | 15 | 6.27 | 10.53 | 89.02 | 136 |
| 12 | 15 | 6.91 | 4.9 | 76.19 | 226 |
| 13 | 20 | 9.70 | 5.3 | 68.51 | 522 |
| 14 | 20 | 9.57 | 8.41 | 95.36 | 81 |
| 15 | 20 | 8.80 | 5.52 | 80.93 | 235 |
Maximum pharmacokinetic parameters of the first IT course consisting of 4 infusions over a 4-hour period every other day.
Abbreviations: Cmax , peak serum concentration; T1/2max , maximum elimination half-life; AUCmax , maximum area under the concentration versus time curve; Clmax , maximum clearance.