Presenting Features of Children With CD2+CD19+ Biphenotypic ALL
| Variable . | Category . | CD2+CD19+ ALL (N = 77) . | B-Lineage ALL . | P Value* . | T-Lineage ALL . | P Value† . | |||
|---|---|---|---|---|---|---|---|---|---|
| . | . | N . | (%) . | (N = 1,631) . | . | (N = 347) . | . | ||
| . | . | . | . | N . | (%) . | . | N . | (%) . | . |
| Age (yr) | <1 | 1 | (1.3) | 71 | (4.4) | .01 | 3 | (0.9) | .87 |
| 1-9 | 51 | (66.2) | 1,245 | (76.3) | 223 | (64.3) | |||
| >10 | 25 | (32.5) | 315 | (19.3) | 121 | (34.9) | |||
| WBC (×109/L) | 1-19 | 57 | (74.0) | 986 | (60.5) | .04 | 119 | (34.3) | <.0001 |
| 20-49 | 12 | (15.6) | 299 | (18.3) | 40 | (11.5) | |||
| ≥50 | 8 | (10.4) | 346 | (21.2) | 188 | (54.2) | |||
| Sex | Male | 39 | (50.6) | 860 | (52.7) | .81 | 248 | (71.5) | .0007 |
| Female | 38 | (49.4) | 771 | (47.3) | 99 | (28.5) | |||
| Race | White | 57 | (74.0) | 1,246 | (76.4) | .86 | 253 | (73.1) | .24 |
| Black | 3 | (3.9) | 66 | (4.0) | 32 | (9.2) | |||
| Other | 17 | (22.1) | 319 | (19.6) | 61 | (17.6) | |||
| Down syndrome | Yes | 1 | (1.3) | 37 | (2.3) | .87 | 5 | (1.4) | .66 |
| No | 76 | (98.7) | 1,592 | (97.7) | 341 | (98.6) | |||
| Liver | Normal | 45 | (58.4) | 770 | (47.3) | .13 | 152 | (44.3) | .03 |
| Mod. enlarg.‡ | 31 | (40.3) | 805 | (49.4) | 168 | (49.0) | |||
| Markedly enlarg. | 1 | (1.3) | 54 | (3.3) | 23 | (6.7) | |||
| Spleen | Normal | 42 | (54.5) | 742 | (45.5) | .30 | 138 | (39.8) | .01 |
| Mod. enlarg. | 32 | (41.6) | 807 | (49.5) | 161 | (46.4) | |||
| Markedly enlarg. | 3 | (3.9) | 82 | (5.0) | 48 | (13.8) | |||
| Lymph nodes | Normal | 46 | (59.7) | 923 | (56.6) | .22 | 108 | (31.1) | <.0001 |
| Mod. enlarg. | 31 | (40.3) | 647 | (39.7) | 149 | (42.9) | |||
| Markedly enlarg. | 0 | (0.0) | 61 | (3.7) | 90 | (25.9) | |||
| Mediastinal mass | Absent | 73 | (94.8) | 1,593 | (97.7) | .02 | 202 | (58.2) | <.0001 |
| Small | 2 | (2.6) | 32 | (2.0) | 40 | (11.5) | |||
| Large | 2 | (2.6) | 6 | (0.4) | 105 | (30.3) | |||
| Hemoglobin (g/dL) | 1-7.9 | 43 | (55.8) | 961 | (59.5) | .26 | 108 | (31.7) | <.0001 |
| 8.0.-10.9 | 30 | (39.0) | 508 | (31.5) | 120 | (35.2) | |||
| ≥11.0 | 4 | (5.2) | 146 | (9.0) | 113 | (33.1) | |||
| Platelets (×109/L) | 1-49 | 26 | (33.8) | 841 | (51.6) | .002 | 123 | (35.5) | .81 |
| 50-149 | 27 | (35.1) | 503 | (30.9) | 128 | (37.0) | |||
| ≥150 | 24 | (31.2) | 285 | (17.5) | 95 | (27.5) | |||
| CNS disease at diagnosis | Yes | 2 | (2.6) | 32 | (2.0) | .97 | 24 | (7.0) | .23 |
| No | 75 | (97.4) | 1,587 | (98.0) | 318 | (93.0) | |||
| NCI risk category | Standard | 44 | (57.1) | 1,007 | (61.7) | .49 | 105 | (30.3) | <.0001 |
| Poor | 33 | (42.9) | 624 | (38.3) | 242 | (69.7) | |||
| Karyotypic features | |||||||||
| 1.Number | Normal (46) | 13 | (37.1) | 159 | (26.0) | .45 | 60 | (39.5) | <.0001 |
| Hypodiploid (<46) | 3 | (8.6) | 38 | (6.2) | 4 | (2.6) | |||
| Psuedodiploid (46) | 5 | (14.3) | 159 | (26.0) | 70 | (46.1) | |||
| Hyperdiploid (47-50) | 4 | (11.4) | 66 | (10.8) | 16 | (10.5) | |||
| Hyperdiploid (>50) | 10 | (28.6) | 189 | (30.9) | 2 | (1.3) | |||
| 2.Aberrations | Normal | 13 | (37.1) | 159 | (26.0) | .21 | 60 | (39.5) | .95 |
| Abnormal | 22 | (62.9) | 452 | (74.0) | 92 | (60.5) | |||
| 3.Translocations | t(4; 11) present | 0 | (0.0) | 21 | (3.4) | .53 | 0 | (0.0) | >.99 |
| t(4; 11) absent | 35 | (100.0) | 590 | (96.6) | 152 | (100.0) | |||
| t(9; 22) present | 0 | (0.0) | 18 | (2.9) | .62 | 1 | (0.7) | .42 | |
| t(9; 22) absent | 35 | (100.0) | 593 | (97.1) | 151 | (99.3) | |||
| Variable . | Category . | CD2+CD19+ ALL (N = 77) . | B-Lineage ALL . | P Value* . | T-Lineage ALL . | P Value† . | |||
|---|---|---|---|---|---|---|---|---|---|
| . | . | N . | (%) . | (N = 1,631) . | . | (N = 347) . | . | ||
| . | . | . | . | N . | (%) . | . | N . | (%) . | . |
| Age (yr) | <1 | 1 | (1.3) | 71 | (4.4) | .01 | 3 | (0.9) | .87 |
| 1-9 | 51 | (66.2) | 1,245 | (76.3) | 223 | (64.3) | |||
| >10 | 25 | (32.5) | 315 | (19.3) | 121 | (34.9) | |||
| WBC (×109/L) | 1-19 | 57 | (74.0) | 986 | (60.5) | .04 | 119 | (34.3) | <.0001 |
| 20-49 | 12 | (15.6) | 299 | (18.3) | 40 | (11.5) | |||
| ≥50 | 8 | (10.4) | 346 | (21.2) | 188 | (54.2) | |||
| Sex | Male | 39 | (50.6) | 860 | (52.7) | .81 | 248 | (71.5) | .0007 |
| Female | 38 | (49.4) | 771 | (47.3) | 99 | (28.5) | |||
| Race | White | 57 | (74.0) | 1,246 | (76.4) | .86 | 253 | (73.1) | .24 |
| Black | 3 | (3.9) | 66 | (4.0) | 32 | (9.2) | |||
| Other | 17 | (22.1) | 319 | (19.6) | 61 | (17.6) | |||
| Down syndrome | Yes | 1 | (1.3) | 37 | (2.3) | .87 | 5 | (1.4) | .66 |
| No | 76 | (98.7) | 1,592 | (97.7) | 341 | (98.6) | |||
| Liver | Normal | 45 | (58.4) | 770 | (47.3) | .13 | 152 | (44.3) | .03 |
| Mod. enlarg.‡ | 31 | (40.3) | 805 | (49.4) | 168 | (49.0) | |||
| Markedly enlarg. | 1 | (1.3) | 54 | (3.3) | 23 | (6.7) | |||
| Spleen | Normal | 42 | (54.5) | 742 | (45.5) | .30 | 138 | (39.8) | .01 |
| Mod. enlarg. | 32 | (41.6) | 807 | (49.5) | 161 | (46.4) | |||
| Markedly enlarg. | 3 | (3.9) | 82 | (5.0) | 48 | (13.8) | |||
| Lymph nodes | Normal | 46 | (59.7) | 923 | (56.6) | .22 | 108 | (31.1) | <.0001 |
| Mod. enlarg. | 31 | (40.3) | 647 | (39.7) | 149 | (42.9) | |||
| Markedly enlarg. | 0 | (0.0) | 61 | (3.7) | 90 | (25.9) | |||
| Mediastinal mass | Absent | 73 | (94.8) | 1,593 | (97.7) | .02 | 202 | (58.2) | <.0001 |
| Small | 2 | (2.6) | 32 | (2.0) | 40 | (11.5) | |||
| Large | 2 | (2.6) | 6 | (0.4) | 105 | (30.3) | |||
| Hemoglobin (g/dL) | 1-7.9 | 43 | (55.8) | 961 | (59.5) | .26 | 108 | (31.7) | <.0001 |
| 8.0.-10.9 | 30 | (39.0) | 508 | (31.5) | 120 | (35.2) | |||
| ≥11.0 | 4 | (5.2) | 146 | (9.0) | 113 | (33.1) | |||
| Platelets (×109/L) | 1-49 | 26 | (33.8) | 841 | (51.6) | .002 | 123 | (35.5) | .81 |
| 50-149 | 27 | (35.1) | 503 | (30.9) | 128 | (37.0) | |||
| ≥150 | 24 | (31.2) | 285 | (17.5) | 95 | (27.5) | |||
| CNS disease at diagnosis | Yes | 2 | (2.6) | 32 | (2.0) | .97 | 24 | (7.0) | .23 |
| No | 75 | (97.4) | 1,587 | (98.0) | 318 | (93.0) | |||
| NCI risk category | Standard | 44 | (57.1) | 1,007 | (61.7) | .49 | 105 | (30.3) | <.0001 |
| Poor | 33 | (42.9) | 624 | (38.3) | 242 | (69.7) | |||
| Karyotypic features | |||||||||
| 1.Number | Normal (46) | 13 | (37.1) | 159 | (26.0) | .45 | 60 | (39.5) | <.0001 |
| Hypodiploid (<46) | 3 | (8.6) | 38 | (6.2) | 4 | (2.6) | |||
| Psuedodiploid (46) | 5 | (14.3) | 159 | (26.0) | 70 | (46.1) | |||
| Hyperdiploid (47-50) | 4 | (11.4) | 66 | (10.8) | 16 | (10.5) | |||
| Hyperdiploid (>50) | 10 | (28.6) | 189 | (30.9) | 2 | (1.3) | |||
| 2.Aberrations | Normal | 13 | (37.1) | 159 | (26.0) | .21 | 60 | (39.5) | .95 |
| Abnormal | 22 | (62.9) | 452 | (74.0) | 92 | (60.5) | |||
| 3.Translocations | t(4; 11) present | 0 | (0.0) | 21 | (3.4) | .53 | 0 | (0.0) | >.99 |
| t(4; 11) absent | 35 | (100.0) | 590 | (96.6) | 152 | (100.0) | |||
| t(9; 22) present | 0 | (0.0) | 18 | (2.9) | .62 | 1 | (0.7) | .42 | |
| t(9; 22) absent | 35 | (100.0) | 593 | (97.1) | 151 | (99.3) | |||