Factor V Haplotype Distribution of Normal and Homozygous APC-Resistant Subjects Based on Use of Three Dimorphisms in Exons 11, 13, and 16 Located 3′ to nt 1691
| Haplotype . | Controls (nt 1691G) . | Homozygous (nt 1691A) . | ||||
|---|---|---|---|---|---|---|
| Exon 11 . | Exon 13 . | Exon 16 . | Alleles (N) . | Fraction . | Alleles (N) . | Fraction . |
| + | + | + | 158 | 0.760 | 230 | 0.991 |
| + | − | − | 25 | 0.120 | 1 | 0.004 |
| + | − | + | 11 | 0.053 | 0 | 0 |
| + | + | − | 6 | 0.029 | 1 | 0.004 |
| 3 additional haplotypes | 8 | 0.038 | 0 | 0 | ||
| Haplotype . | Controls (nt 1691G) . | Homozygous (nt 1691A) . | ||||
|---|---|---|---|---|---|---|
| Exon 11 . | Exon 13 . | Exon 16 . | Alleles (N) . | Fraction . | Alleles (N) . | Fraction . |
| + | + | + | 158 | 0.760 | 230 | 0.991 |
| + | − | − | 25 | 0.120 | 1 | 0.004 |
| + | − | + | 11 | 0.053 | 0 | 0 |
| + | + | − | 6 | 0.029 | 1 | 0.004 |
| 3 additional haplotypes | 8 | 0.038 | 0 | 0 | ||
The normal and APC-resistant subjects gave 208 and 232 informative alleles and 126 and 2 uninformative alleles, respectively.