Factor V Haplotype Distribution of Normal and Homozygous APC-Resistant Subjects Based on Use of Three Dimorphisms in Exons 2, 4, and 9 Located 5′ to nt 1691
| Haplotype . | Controls (nt G1691) . | Homozygous (nt A1691) . | ||||
|---|---|---|---|---|---|---|
| Exon 2 . | Exon 4 . | Exon 9 . | Alleles (N) . | Fraction . | Alleles (N) . | Fraction . |
| − | − | + | 156 | 0.578 | 207 | 0.885 |
| + | − | + | 56 | 0.207 | 19 | 0.081 |
| − | + | + | 40 | 0.148 | 8 | 0.034 |
| 3 additional haplotyes | 18 | 0.067 | 0 | 0 | ||
| Haplotype . | Controls (nt G1691) . | Homozygous (nt A1691) . | ||||
|---|---|---|---|---|---|---|
| Exon 2 . | Exon 4 . | Exon 9 . | Alleles (N) . | Fraction . | Alleles (N) . | Fraction . |
| − | − | + | 156 | 0.578 | 207 | 0.885 |
| + | − | + | 56 | 0.207 | 19 | 0.081 |
| − | + | + | 40 | 0.148 | 8 | 0.034 |
| 3 additional haplotyes | 18 | 0.067 | 0 | 0 | ||
The normal and APC-resistant subjects gave 270 and 234 informative alleles and 64 and 0 uninformative alleles, respectively.