Genotypes of live offspring from Mekk1ΔKD/+ intercrosses, Mekk1ΔKD/+ Jnk2-/- intercrosses, and Mekk1ΔKD/+ Jnk1-/- intercrosses
. | MEKK1 genotype . | . | . | . | JNK2 genotype . | . | . | . | JNK1 genotype . | . | . | . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stage . | Total (no. of litters) . | Wt (%) . | Mekk1ΔKD/+ (%) . | Mekk1ΔKD (%) . | Total (no. of litters) . | Jnk2-/- (%) . | Jnk2-/- Mekk1ΔKD/+ (%) . | Jnk2-/- Mekk1ΔKD (%) . | Total (no. of litters) . | Jnk1-/- (%) . | Jnk1-/- Mekk1ΔKD/+ (%) . | Jnk1-/- Mekk1ΔKD (%) . | |||||||||
| E8.5 | 9 (1) | 1 (11) | 7 (78) | 1 (11) | ND | ND | ND | ND | ND | ND | ND | ND | |||||||||
| E10.5 | 9 (1) | 3 (33) | 4 (44) | 2 (22) | 6 (1) | 1 (17) | 3 (50) | 2 (33) | ND | ND | ND | ND | |||||||||
| E12.5 | ND | ND | ND | ND | 53 (6) | 13 (25) | 28 (53) | 12 (23) | ND | ND | ND | ND | |||||||||
| E13.5 | 68 (12) | 18 (26) | 29 (43) | 21 (31) | 78 (12) | 23 (29) | 40 (51) | 15 (19) | 11 (2) | 1 (9) | 7 (63) | 3 (27) | |||||||||
| E14.5 | 125 (19) | 38 (30) | 60 (48) | 27 (22) | 75 (12) | 31 (41) | 29 (39) | 15 (20) | 6 (2) | 0 (0) | 5 (83) | 1 (17) | |||||||||
| E15.5 | 70 (9) | 17 (24) | 47 (67) | 6 (9) | 41 (7) | 7 (17) | 28 (68) | 6 (15) | 8 (2) | 3 (37) | 5 (62) | 0 (0) | |||||||||
| E16.5 | 22 (3) | 8 (36) | 13 (59) | 1 (5) | 16 (3) | 4 (25) | 11 (69) | 1 (6) | ND | ND | ND | ND | |||||||||
| E17.5 | 18 (3) | 5 (28) | 12 (67) | 1 (5) | 36 (5) | 10 (28) | 26 (72) | 0 (0) | ND | ND | ND | ND | |||||||||
| E18.5 | 13 (2) | 4 (31) | 9 (69) | 0 (0) | ND | ND | ND | ND | 3 (1) | 1 (33) | 2 (66) | 0 (0) | |||||||||
| Postnatal | 217 (42) | 78 (36) | 135 (62) | 4 (2) | 291 (57) | 115 (40) | 176 (60) | 0 (0) | 30 (11) | 11 (37) | 19 (63) | 0 (0) | |||||||||
. | MEKK1 genotype . | . | . | . | JNK2 genotype . | . | . | . | JNK1 genotype . | . | . | . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stage . | Total (no. of litters) . | Wt (%) . | Mekk1ΔKD/+ (%) . | Mekk1ΔKD (%) . | Total (no. of litters) . | Jnk2-/- (%) . | Jnk2-/- Mekk1ΔKD/+ (%) . | Jnk2-/- Mekk1ΔKD (%) . | Total (no. of litters) . | Jnk1-/- (%) . | Jnk1-/- Mekk1ΔKD/+ (%) . | Jnk1-/- Mekk1ΔKD (%) . | |||||||||
| E8.5 | 9 (1) | 1 (11) | 7 (78) | 1 (11) | ND | ND | ND | ND | ND | ND | ND | ND | |||||||||
| E10.5 | 9 (1) | 3 (33) | 4 (44) | 2 (22) | 6 (1) | 1 (17) | 3 (50) | 2 (33) | ND | ND | ND | ND | |||||||||
| E12.5 | ND | ND | ND | ND | 53 (6) | 13 (25) | 28 (53) | 12 (23) | ND | ND | ND | ND | |||||||||
| E13.5 | 68 (12) | 18 (26) | 29 (43) | 21 (31) | 78 (12) | 23 (29) | 40 (51) | 15 (19) | 11 (2) | 1 (9) | 7 (63) | 3 (27) | |||||||||
| E14.5 | 125 (19) | 38 (30) | 60 (48) | 27 (22) | 75 (12) | 31 (41) | 29 (39) | 15 (20) | 6 (2) | 0 (0) | 5 (83) | 1 (17) | |||||||||
| E15.5 | 70 (9) | 17 (24) | 47 (67) | 6 (9) | 41 (7) | 7 (17) | 28 (68) | 6 (15) | 8 (2) | 3 (37) | 5 (62) | 0 (0) | |||||||||
| E16.5 | 22 (3) | 8 (36) | 13 (59) | 1 (5) | 16 (3) | 4 (25) | 11 (69) | 1 (6) | ND | ND | ND | ND | |||||||||
| E17.5 | 18 (3) | 5 (28) | 12 (67) | 1 (5) | 36 (5) | 10 (28) | 26 (72) | 0 (0) | ND | ND | ND | ND | |||||||||
| E18.5 | 13 (2) | 4 (31) | 9 (69) | 0 (0) | ND | ND | ND | ND | 3 (1) | 1 (33) | 2 (66) | 0 (0) | |||||||||
| Postnatal | 217 (42) | 78 (36) | 135 (62) | 4 (2) | 291 (57) | 115 (40) | 176 (60) | 0 (0) | 30 (11) | 11 (37) | 19 (63) | 0 (0) | |||||||||
Surviving fetuses were defined as those with beating heart at the time of dissection. Unless noted otherwise, data are expressed as the number of embryos, with percentages within parenthesis.
ND indicates not determined.