Identified MHC class 1 and trafficking-regulating receptors after MS/MS proteomic analysis of mother and patient B CANK-cell–derived, membrane-enriched protein fractions
Protein family and description . | Accession no. . | Section no. . | Protein-derived peptides, total score . |
|---|---|---|---|
| Mother | |||
| MHC class 1-related proteins | |||
| MHC class 1 antigen | Q9TQG6 | 11 | 65.38 |
| MHC class 1 antigen | Q9GJF5 | 12 | 107.24 |
| MHC class 1 antigen | Q95HA7 | 17 | 48.14 |
| HLA-C heavy chain | Q30203 | 10 | 27.24 |
| HLA-A10 α-chain | HLHU10 | 11 | 183.65 |
| HLA-A2-α-2 | I56009 | 18 | 22.04 |
| HLA-A cell-surface antigen | I54412 | 12 | 97.23 |
| HLA-CW fragment | Q29645 | 11 | 44.98 |
| β2-microglobulin | AAB25312 | 19 | 73.19 |
| MHC class 1 independent inhibitory receptors | |||
| CEACAM1 (CD66a) | ND | ND | ND |
| Trafficking-regulating molecules | |||
| ICAM-3 | S28904 | 4 | 65.76 |
| LFA-1 | ITAL_HUMAN | 3 | 518.12 |
| GPR48 | Q9NYD1 | 3 | 25.76 |
| CD44 | Q9NRY3 | 18 | 39.02 |
| CXCR3 | Q9P2T5 | 16 | 156.12 |
| CCR2 | ND | ND | ND |
| Patient B | |||
| MHC class 1—related proteins | |||
| HLA-C heavy chain | Q30204 | 11 | 30.4 |
| MHC class 1 antigen | Q9GJ38 | 10 | 40.62 |
| MHC class 1 independent inhibitory receptors | |||
| CEACAM1 (CD66a) | P13688 | 19 | 187.23 |
| Trafficking-regulating molecules | |||
| ICAM-3 | S28904 | 4 | 59.08 |
| LFA-1 | ITAL_HUMAN | 3 | 400.79 |
| GPR48 | Q9NYD1 | 3 | 32.67 |
| CD44 | Q9NRY3 | 18 | 27.98 |
| CXCR3 | Q9P2T5 | 16 | 139.66 |
| CCR2 | P41597 | 7 | 341.29 |
Protein family and description . | Accession no. . | Section no. . | Protein-derived peptides, total score . |
|---|---|---|---|
| Mother | |||
| MHC class 1-related proteins | |||
| MHC class 1 antigen | Q9TQG6 | 11 | 65.38 |
| MHC class 1 antigen | Q9GJF5 | 12 | 107.24 |
| MHC class 1 antigen | Q95HA7 | 17 | 48.14 |
| HLA-C heavy chain | Q30203 | 10 | 27.24 |
| HLA-A10 α-chain | HLHU10 | 11 | 183.65 |
| HLA-A2-α-2 | I56009 | 18 | 22.04 |
| HLA-A cell-surface antigen | I54412 | 12 | 97.23 |
| HLA-CW fragment | Q29645 | 11 | 44.98 |
| β2-microglobulin | AAB25312 | 19 | 73.19 |
| MHC class 1 independent inhibitory receptors | |||
| CEACAM1 (CD66a) | ND | ND | ND |
| Trafficking-regulating molecules | |||
| ICAM-3 | S28904 | 4 | 65.76 |
| LFA-1 | ITAL_HUMAN | 3 | 518.12 |
| GPR48 | Q9NYD1 | 3 | 25.76 |
| CD44 | Q9NRY3 | 18 | 39.02 |
| CXCR3 | Q9P2T5 | 16 | 156.12 |
| CCR2 | ND | ND | ND |
| Patient B | |||
| MHC class 1—related proteins | |||
| HLA-C heavy chain | Q30204 | 11 | 30.4 |
| MHC class 1 antigen | Q9GJ38 | 10 | 40.62 |
| MHC class 1 independent inhibitory receptors | |||
| CEACAM1 (CD66a) | P13688 | 19 | 187.23 |
| Trafficking-regulating molecules | |||
| ICAM-3 | S28904 | 4 | 59.08 |
| LFA-1 | ITAL_HUMAN | 3 | 400.79 |
| GPR48 | Q9NYD1 | 3 | 32.67 |
| CD44 | Q9NRY3 | 18 | 27.98 |
| CXCR3 | Q9P2T5 | 16 | 139.66 |
| CCR2 | P41597 | 7 | 341.29 |
ND indicates not detected.