Peptides derived from the HOM-TES-14/SCP1 antigen selected for this study
. | . | Binding probability to HLA-DRB1 . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sequence . | Position . | *0101* . | *0301* . | *0401* . | *0701* . | *1101* . | *1501* . | |||||
| KEDYEKIQHLEQEYK | p244-258 | 18 | 1 | 28 | 16 | 24 | 10 | |||||
| LTKELEDIKVSLQRS | p320-334 | 8 | 28 | 12 | 8 | 8 | 10 | |||||
| QKALEEDLQIATKTI | p338-352 | 8 | 29 | 26 | 8 | 6 | 20 | |||||
| EVELEELKKVLGEKE | p430-444 | 16 | 20 | 14 | 8 | 27 | 27 | |||||
| EIQLTAITTSEQYYS | p482-496 | 21 | 11 | 26 | 22 | 14 | 18 | |||||
| QLNVYEIKVNKLELE | p635-349 | 23 | 22 | 20 | 22 | 13 | 14 | |||||
| KAKVIADEAVKLQKE | p684-698 | 26 | 32 | 20 | 16 | 7 | 24 | |||||
| QSSLRASLEIELSNL | p742-756 | 18 | 26 | 14 | 28 | 6 | 20 | |||||
| SRNFTSVDHGISKDK | p821-835 | 25 | 10 | 28 | 10 | 33 | 12 | |||||
| DHGISKDKRDYLWTS | p828-842 | 18 | 35 | 26 | 16 | 14 | 14 | |||||
| DYLWTSAKNTLSTPL | p837-851 | 20 | 10 | 28 | 22 | 19 | 8 | |||||
| STPLPKAYTVKTPTK | p848-862 | 17 | 12 | 26 | 22 | 7 | 24 | |||||
| LSMVSEEETLKTLYR | p901-915 | 16 | 14 | 26 | 16 | 7 | 24 | |||||
| TLKFGAIRKMREDRW | p942-956 | 16 | 14 | 16 | 16 | 26 | 14 | |||||
. | . | Binding probability to HLA-DRB1 . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sequence . | Position . | *0101* . | *0301* . | *0401* . | *0701* . | *1101* . | *1501* . | |||||
| KEDYEKIQHLEQEYK | p244-258 | 18 | 1 | 28 | 16 | 24 | 10 | |||||
| LTKELEDIKVSLQRS | p320-334 | 8 | 28 | 12 | 8 | 8 | 10 | |||||
| QKALEEDLQIATKTI | p338-352 | 8 | 29 | 26 | 8 | 6 | 20 | |||||
| EVELEELKKVLGEKE | p430-444 | 16 | 20 | 14 | 8 | 27 | 27 | |||||
| EIQLTAITTSEQYYS | p482-496 | 21 | 11 | 26 | 22 | 14 | 18 | |||||
| QLNVYEIKVNKLELE | p635-349 | 23 | 22 | 20 | 22 | 13 | 14 | |||||
| KAKVIADEAVKLQKE | p684-698 | 26 | 32 | 20 | 16 | 7 | 24 | |||||
| QSSLRASLEIELSNL | p742-756 | 18 | 26 | 14 | 28 | 6 | 20 | |||||
| SRNFTSVDHGISKDK | p821-835 | 25 | 10 | 28 | 10 | 33 | 12 | |||||
| DHGISKDKRDYLWTS | p828-842 | 18 | 35 | 26 | 16 | 14 | 14 | |||||
| DYLWTSAKNTLSTPL | p837-851 | 20 | 10 | 28 | 22 | 19 | 8 | |||||
| STPLPKAYTVKTPTK | p848-862 | 17 | 12 | 26 | 22 | 7 | 24 | |||||
| LSMVSEEETLKTLYR | p901-915 | 16 | 14 | 26 | 16 | 7 | 24 | |||||
| TLKFGAIRKMREDRW | p942-956 | 16 | 14 | 16 | 16 | 26 | 14 | |||||
Indicated are the scores of the concerning peptides obtained by epitope prediction using SYFPEITHI database. Scores of 20 or above are considered as predicting a high probability of binding to the respective HLA-DR subtype.
Allele frequency in the white population: 8.7% for *0101, 10% for *0301, 8% for *0401, 11.7% for *0701, 8.3% for *1101, and 12.1% for *1501.