Commonly altered chromosomal regions in different subgroups of DLBCL
. | Whole series, n (%); N = 224 . | ABC, n (%); n = 77 . | GCB, n (%); n = 87 . | PMBCL, n (%); n = 19 . | Unclassified, n (%); n = 41 . |
|---|---|---|---|---|---|
| Altered cases | 164 (73) | 63 (81) | 63 (72) | 16 (84) | 22 (54) |
| Mean no. of alterations | 3.3 | 4.5 | 3.1 | 3.3 | 1.7 |
| Mean no. of gains | 1.9 | 2.5 | 1.6 | 2.1 | 1.0 |
| Mean no. of amplifications | 0.3 | 0.4 | 0.3 | 0.4 | 0.0 |
| Mean no. of losses | 1.2 | 1.6 | 1.1 | 0.8 | 0.6 |
| Gains | |||||
| Xp | 27 (12) | 12 (16) | 12 (14) | 3 (16) | 0 (0) |
| 1q25-q32 | 26 (12) | 9 (12) | 9 (10) | 1 (5) | 7 (17) |
| 2p14-p16* | 39 (17) | 12 (15) | 15 (17) | 9 (47) | 3 (7) |
| Trisomy 3* | 14 (6) | 12 (15) | 0 (0) | 1 (5) | 1 (2) |
| 3p* | 28 (12) | 24 (31) | 1 (1) | 1 (5) | 2 (5) |
| 3q† | 22 (10) | 20 (26) | 0 (0) | 1 (5) | 1 (2) |
| 3q27-qter† | 35 (16) | 26 (33) | 4 (5) | 3 (16) | 2 (5) |
| 6p | 30 (13) | 13 (17) | 11 (13) | 1 (5) | 5 (12) |
| 7p | 22 (10) | 8 (10) | 13 (15) | 1 (5) | 0 (0) |
| 7q | 25 (11) | 10 (13) | 13 (15) | 1 (5) | 1 (2) |
| 8q23-qter | 23 (10) | 8 (10) | 10 (11) | 2 (11) | 3 (7) |
| 9p† | 14 (6) | 5 (6) | 0 (0) | 7 (37) | 2 (5) |
| 12p | 19 (8) | 4 (5) | 14 (16) | 1 (5) | 0 (0) |
| 12q12‡ | 24 (11) | 4 (5) | 18 (21) | 1 (5) | 1 (2) |
| 12q22-qter | 22 (10) | 7 (9) | 13 (15) | 1 (5) | 1 (2) |
| 18q21-q22* | 42 (19) | 26 (34) | 9 (10) | 3 (16) | 4 (10) |
| Losses | |||||
| 6q16 | 50 (22) | 26 (34) | 19 (22) | 0 (0) | 5 (12) |
| 6q21-c22* | 55 (25) | 31 (40) | 19 (22) | 0 (0) | 5 (12) |
| 8p22-pter | 19 (8) | 8 (10) | 3 (3) | 3 (16) | 5 (12) |
| 17p | 22 (10) | 14 (18) | 7 (8) | 0 (0) | 1 (2) |
. | Whole series, n (%); N = 224 . | ABC, n (%); n = 77 . | GCB, n (%); n = 87 . | PMBCL, n (%); n = 19 . | Unclassified, n (%); n = 41 . |
|---|---|---|---|---|---|
| Altered cases | 164 (73) | 63 (81) | 63 (72) | 16 (84) | 22 (54) |
| Mean no. of alterations | 3.3 | 4.5 | 3.1 | 3.3 | 1.7 |
| Mean no. of gains | 1.9 | 2.5 | 1.6 | 2.1 | 1.0 |
| Mean no. of amplifications | 0.3 | 0.4 | 0.3 | 0.4 | 0.0 |
| Mean no. of losses | 1.2 | 1.6 | 1.1 | 0.8 | 0.6 |
| Gains | |||||
| Xp | 27 (12) | 12 (16) | 12 (14) | 3 (16) | 0 (0) |
| 1q25-q32 | 26 (12) | 9 (12) | 9 (10) | 1 (5) | 7 (17) |
| 2p14-p16* | 39 (17) | 12 (15) | 15 (17) | 9 (47) | 3 (7) |
| Trisomy 3* | 14 (6) | 12 (15) | 0 (0) | 1 (5) | 1 (2) |
| 3p* | 28 (12) | 24 (31) | 1 (1) | 1 (5) | 2 (5) |
| 3q† | 22 (10) | 20 (26) | 0 (0) | 1 (5) | 1 (2) |
| 3q27-qter† | 35 (16) | 26 (33) | 4 (5) | 3 (16) | 2 (5) |
| 6p | 30 (13) | 13 (17) | 11 (13) | 1 (5) | 5 (12) |
| 7p | 22 (10) | 8 (10) | 13 (15) | 1 (5) | 0 (0) |
| 7q | 25 (11) | 10 (13) | 13 (15) | 1 (5) | 1 (2) |
| 8q23-qter | 23 (10) | 8 (10) | 10 (11) | 2 (11) | 3 (7) |
| 9p† | 14 (6) | 5 (6) | 0 (0) | 7 (37) | 2 (5) |
| 12p | 19 (8) | 4 (5) | 14 (16) | 1 (5) | 0 (0) |
| 12q12‡ | 24 (11) | 4 (5) | 18 (21) | 1 (5) | 1 (2) |
| 12q22-qter | 22 (10) | 7 (9) | 13 (15) | 1 (5) | 1 (2) |
| 18q21-q22* | 42 (19) | 26 (34) | 9 (10) | 3 (16) | 4 (10) |
| Losses | |||||
| 6q16 | 50 (22) | 26 (34) | 19 (22) | 0 (0) | 5 (12) |
| 6q21-c22* | 55 (25) | 31 (40) | 19 (22) | 0 (0) | 5 (12) |
| 8p22-pter | 19 (8) | 8 (10) | 3 (3) | 3 (16) | 5 (12) |
| 17p | 22 (10) | 14 (18) | 7 (8) | 0 (0) | 1 (2) |