Main features of the 14 patients with HIT
. | . | . | . | Previous heparin exposure . | . | . | . | . | . | . | . | . | . | . | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patient no. . | Age, y . | Sex . | Cancer present . | Previous exposure . | Time since exposure . | Setting . | Drug . | Dosage . | Time to HIT, d . | Platelet count, × 109/L, baseline/nadir . | IgG ELISA OD . | HIPA . | TE . | Time to TE d . | |
1 | 73 | M | Yes | Yes | 4 mo | In hospital | Nadroparin | High | 5 | 259/127 | 0.8 | Negative | No | NA | |
2 | 26 | M | Yes | No | NA | In hospital | Nadroparin | High | 7 | 249/18 | 1.3 | Positive | No | NA | |
3 | 74 | M | No | Yes | 2 y | In hospital | Nadroparin | High | 12 | 150/32 | >2.0 | Positive | TIA | 14 | |
4 | 84 | F | Yes | Yes | 5 wk | In hospital | Enoxaparin | High | 2 | 231/83 | >2.0 | Positive | No | NA | |
5 | 83 | F | No | Yes | 5 mo | In hospital | Dalteparin | Low | 5 | 209/68 | 1.8 | Positive | No | NA | |
6 | 73 | M | Yes | Yes | 6 mo | In hospital | Nadroparin | Intermediate | 9 | 210/70 | >2.0 | Positive | Ischemic stroke | 12 | |
7 | 83 | M | No | No | NA | In hospital | Nadroparin | Low | 12 | 214/30 | 1.1 | Positive | No | NA | |
8 | 63 | M | No | Yes | 5 mo | At home | Dalteparin | Low | 5 | 186/50 | 0.9 | Negative | No | NA | |
9 | 22 | M | No | Yes | 12 mo | At home | Enoxaparin | Intermediate | 9 | 232/68 | 1.4 | Positive | DVT | 11 | |
10 | 23 | M | No | No | NA | At home | Nadroparin | Intermediate | 9 | 248/65 | 1.2 | Positive | No | NA | |
11 | 65 | F | No | Yes | 4 mo | At home | Enoxaparin | Intermediate | 4 | 313/67 | 1.0 | Positive | No | NA | |
12 | 44 | F | No | Yes | 8 mo | At home | Nadroparin | High | 6 | 365/124 | 1.0 | Negative | No | NA | |
13 | 38 | M | No | No | NA | At home | Nadroparin | Intermediate | 13 | 234/90 | 1.2 | Positive | No | NA | |
14 | 72 | F | No | Yes | 6 mo | At home | Nadroparin | High | 5 | 255/88 | >2.0 | Positive | Extension of DVT | 6 |
. | . | . | . | Previous heparin exposure . | . | . | . | . | . | . | . | . | . | . | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patient no. . | Age, y . | Sex . | Cancer present . | Previous exposure . | Time since exposure . | Setting . | Drug . | Dosage . | Time to HIT, d . | Platelet count, × 109/L, baseline/nadir . | IgG ELISA OD . | HIPA . | TE . | Time to TE d . | |
1 | 73 | M | Yes | Yes | 4 mo | In hospital | Nadroparin | High | 5 | 259/127 | 0.8 | Negative | No | NA | |
2 | 26 | M | Yes | No | NA | In hospital | Nadroparin | High | 7 | 249/18 | 1.3 | Positive | No | NA | |
3 | 74 | M | No | Yes | 2 y | In hospital | Nadroparin | High | 12 | 150/32 | >2.0 | Positive | TIA | 14 | |
4 | 84 | F | Yes | Yes | 5 wk | In hospital | Enoxaparin | High | 2 | 231/83 | >2.0 | Positive | No | NA | |
5 | 83 | F | No | Yes | 5 mo | In hospital | Dalteparin | Low | 5 | 209/68 | 1.8 | Positive | No | NA | |
6 | 73 | M | Yes | Yes | 6 mo | In hospital | Nadroparin | Intermediate | 9 | 210/70 | >2.0 | Positive | Ischemic stroke | 12 | |
7 | 83 | M | No | No | NA | In hospital | Nadroparin | Low | 12 | 214/30 | 1.1 | Positive | No | NA | |
8 | 63 | M | No | Yes | 5 mo | At home | Dalteparin | Low | 5 | 186/50 | 0.9 | Negative | No | NA | |
9 | 22 | M | No | Yes | 12 mo | At home | Enoxaparin | Intermediate | 9 | 232/68 | 1.4 | Positive | DVT | 11 | |
10 | 23 | M | No | No | NA | At home | Nadroparin | Intermediate | 9 | 248/65 | 1.2 | Positive | No | NA | |
11 | 65 | F | No | Yes | 4 mo | At home | Enoxaparin | Intermediate | 4 | 313/67 | 1.0 | Positive | No | NA | |
12 | 44 | F | No | Yes | 8 mo | At home | Nadroparin | High | 6 | 365/124 | 1.0 | Negative | No | NA | |
13 | 38 | M | No | No | NA | At home | Nadroparin | Intermediate | 13 | 234/90 | 1.2 | Positive | No | NA | |
14 | 72 | F | No | Yes | 6 mo | At home | Nadroparin | High | 5 | 255/88 | >2.0 | Positive | Extension of DVT | 6 |
ELISA indicates enzyme-linked immunosorbent assay; TE, thromboembolism; TIA, transitory ischemic attack; NA, not applicable.