Table 3.

AMN107 inhibition of FIP1L1-PDGFRα




IC50, nM
MSCV-GFP   n/a  
FIP1L1-PDGFRα   23  
FIP1L1-PDGFRα T674I   n/a  
PDGFRα D842V
 
n/a
 



IC50, nM
MSCV-GFP   n/a  
FIP1L1-PDGFRα   23  
FIP1L1-PDGFRα T674I   n/a  
PDGFRα D842V
 
n/a
 

IC50 = AMN 107 concentration resulting in 50% growth inhibition of Ba/F3 cells stably transduced with the constructs listed.

n/a indicates that 50% inhibition of cell growth was not achieved at the highest drug concentration tested.

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