Table 2.

AMN107 inhibition of TEL-PDGFRβ and TEL-PDGFRβ T681I




IC50, nM
Ba/F3   n/a  
TEL-PDGFRβ   18.1  
TEL-PDGFRβ T681I   22.2  
TEL-FGFR3
 
n/a
 



IC50, nM
Ba/F3   n/a  
TEL-PDGFRβ   18.1  
TEL-PDGFRβ T681I   22.2  
TEL-FGFR3
 
n/a
 

IC50 = AMN 107 concentration resulting in 50% growth inhibition of Ba/F3 cells stably transduced with the constructs listed.

n/a indicates that 50% inhibition of cell growth was not achieved at the highest drug concentration tested. Ba/F3 indicates untransduced control cells.

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