AMN107 inhibition of TEL-PDGFRβ and TEL-PDGFRβ T681I
.
IC50, nM
.
Ba/F3
n/a
TEL-PDGFRβ
18.1
TEL-PDGFRβ T681I
22.2
TEL-FGFR3
n/a
.
IC50, nM
.
Ba/F3
n/a
TEL-PDGFRβ
18.1
TEL-PDGFRβ T681I
22.2
TEL-FGFR3
n/a
IC50 = AMN 107 concentration resulting in 50% growth inhibition of Ba/F3 cells stably transduced with the constructs listed.
n/a indicates that 50% inhibition of cell growth was not achieved at the highest drug concentration tested. Ba/F3 indicates untransduced control cells.