Table 1.

Imatinib IC50 values of TEL-PDGFRβ and FIL1P1-PDGFRα constructs




Imatinib IC50

Reference
TEL-PDGFRβ   50 nM  18  
TEL-PDGFRβ T681I   n/a  18  
FIP1L1-PDGFRα   3 nM  7  
FIP1L1-PDGFRα T674I   n/a  7  
PDGFRα D842V
 
∼1 μM
 
27,34 
 



Imatinib IC50

Reference
TEL-PDGFRβ   50 nM  18  
TEL-PDGFRβ T681I   n/a  18  
FIP1L1-PDGFRα   3 nM  7  
FIP1L1-PDGFRα T674I   n/a  7  
PDGFRα D842V
 
∼1 μM
 
27,34 
 

Imatinib concentration resulting in 50% growth inhibition of Ba/F3 cells stably transduced with the constructs used in this study.

n/a indicates that 50% inhibition of cell growth was not achieved at the highest drug concentration tested.

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