Definitions of comorbidities included in the HCT-CI and HCT-CI scores compared with original CCI scores
Comorbidity . | Definitions of comorbidities included in the new HCT-CI . | HCT-CI weighted scores . | Original CCI scores* . |
|---|---|---|---|
| Arrhythmia | Atrial fibrillation or flutter, sick sinus syndrome, or ventricular arrhythmias | 1 | 0 |
| Cardiac‡ | Coronary artery disease, § congestive heart failure, myocardial infarction, or EF ≤ 50% | 1 | 1 |
| Inflammatory bowel disease | Crohn disease or ulcerative colitis | 1 | 0 |
| Diabetes | Requiring treatment with insulin or oral hypoglycemics but not diet alone | 1 | 1 |
| Cerebrovascular disease | Transient ischemic attack or cerebrovascular accident | 1 | 1 |
| Psychiatric disturbance† | Depression or anxiety requiring psychiatric consult or treatment | 1 | Not included |
| Hepatic, mild‡ | Chronic hepatitis, bilirubin > ULN to 1.5 × ULN, or AST/ALT > ULN to 2.5 × ULN | 1 | 1 |
| Obesity† | Patients with a body mass index > 35 kg/m2 | 1 | Not included |
| Infection† | Requiring continuation of antimicrobial treatment after day 0 | 1 | Not included |
| Rheumatologic | SLE, RA, polymyositis, mixed CTD, or polymyalgia rheumatica | 2 | 1 |
| Peptic ulcer | Requiring treatment | 2 | 1 |
| Moderate/severe rena‡ | Serum creatinine > 2 mg/dL, on dialysis, or prior renal transplantation | 2 | 2 |
| Moderate pulmonary‡ | DLco and/or FEV1 66%-80% or dyspnea on slight activity | 2 | 1 |
| Prior solid tumo‡ | Treated at any time point in the patient's past history, excluding nonmelanoma skin cancer | 3 | 2 |
| Heart valve disease | Except mitral valve prolapse | 3 | 0 |
| Severe pulmonary‡ | DLco and/or FEV1 ≤ 65% or dyspnea at rest or requiring oxygen | 3 | 1 |
| Moderate/severe hepatic‡ | Liver cirrhosis, bilirubin > 1.5 × ULN, or AST/ALT > 2.5 × ULN | 3 | 3 |
Comorbidity . | Definitions of comorbidities included in the new HCT-CI . | HCT-CI weighted scores . | Original CCI scores* . |
|---|---|---|---|
| Arrhythmia | Atrial fibrillation or flutter, sick sinus syndrome, or ventricular arrhythmias | 1 | 0 |
| Cardiac‡ | Coronary artery disease, § congestive heart failure, myocardial infarction, or EF ≤ 50% | 1 | 1 |
| Inflammatory bowel disease | Crohn disease or ulcerative colitis | 1 | 0 |
| Diabetes | Requiring treatment with insulin or oral hypoglycemics but not diet alone | 1 | 1 |
| Cerebrovascular disease | Transient ischemic attack or cerebrovascular accident | 1 | 1 |
| Psychiatric disturbance† | Depression or anxiety requiring psychiatric consult or treatment | 1 | Not included |
| Hepatic, mild‡ | Chronic hepatitis, bilirubin > ULN to 1.5 × ULN, or AST/ALT > ULN to 2.5 × ULN | 1 | 1 |
| Obesity† | Patients with a body mass index > 35 kg/m2 | 1 | Not included |
| Infection† | Requiring continuation of antimicrobial treatment after day 0 | 1 | Not included |
| Rheumatologic | SLE, RA, polymyositis, mixed CTD, or polymyalgia rheumatica | 2 | 1 |
| Peptic ulcer | Requiring treatment | 2 | 1 |
| Moderate/severe rena‡ | Serum creatinine > 2 mg/dL, on dialysis, or prior renal transplantation | 2 | 2 |
| Moderate pulmonary‡ | DLco and/or FEV1 66%-80% or dyspnea on slight activity | 2 | 1 |
| Prior solid tumo‡ | Treated at any time point in the patient's past history, excluding nonmelanoma skin cancer | 3 | 2 |
| Heart valve disease | Except mitral valve prolapse | 3 | 0 |
| Severe pulmonary‡ | DLco and/or FEV1 ≤ 65% or dyspnea at rest or requiring oxygen | 3 | 1 |
| Moderate/severe hepatic‡ | Liver cirrhosis, bilirubin > 1.5 × ULN, or AST/ALT > 2.5 × ULN | 3 | 3 |
To convert creatinine from milligrams per deciliter to micromoles per liter, multiply milligrams per deciliter by 88.4.
EF indicates ejection fraction; ULN, upper limit of normal; SLE, systemic lupus erythmatosis; RA, rheumatoid arthritis; CTD, connective tissue disease; DLco, diffusion capacity of carbon monoxide.
Definitions of comorbidities included in the original CCI are defined in the appendix of a prior publication.8
Newly investigated comorbidities.
Comorbidities with modified definitions compared with the original CCI.
One or more vessel-coronary artery stenosis requiring medical treatment, stent, or bypass graft.