Table 3.

Prevalence of comorbidities among 708 patients included in the training set with cumulative incidences and multivariate HRs of comorbidities for 2-year NRM

Comorbidity
Prevalence, %
2-year NRM, %
Multivariate HR*
Bleeding†  1   0   0.0  
Headache†  4   8   0.3  
Osteoarthritis†  1   11   0.4  
Gastrointestinal disease   9   20   0.5  
Coagulopathy   6   30   0.6  
Osteoporosis†  1   75   0.7  
Renal, mild‡  10   24   0.8  
Endocrine disease   5   31   1.0  
Asthma†  2   14   1.1  
Pulmonary, mild‡  16   18   1.1  
Hypertension   10   33   1.2  
Arrhythmia   5   35   1.3  
Cardiac‡  5   37   1.3  
Inflammatory bowel disease   1   31   1.3  
Diabetes   3   50   1.6  
Cerebrovascular disease   < 1   67   1.6  
Psychiatric disturbance†  9   29   1.8  
Hepatic, mild‡  16   30   1.9  
Obesity†  2   33   1.9  
Infection†  4   40   1.9  
Rheumatologic   4   45   2.3  
Peptic ulcer   1   38   2.5  
Renal, moderate/severe‡  2   42   2.6  
Pulmonary, moderate‡  24   36   3.0  
Prior solid tumor‡  2   38   3.1  
Heart valve disease   2   33   3.3  
Pulmonary, severe‡  9   39   3.7  
Hepatic, moderate/severe‡  4   43   3.9  
Peripheral vascular disease
 		 0
 		 —
 		 —
 
Comorbidity
Prevalence, %
2-year NRM, %
Multivariate HR*
Bleeding†  1   0   0.0  
Headache†  4   8   0.3  
Osteoarthritis†  1   11   0.4  
Gastrointestinal disease   9   20   0.5  
Coagulopathy   6   30   0.6  
Osteoporosis†  1   75   0.7  
Renal, mild‡  10   24   0.8  
Endocrine disease   5   31   1.0  
Asthma†  2   14   1.1  
Pulmonary, mild‡  16   18   1.1  
Hypertension   10   33   1.2  
Arrhythmia   5   35   1.3  
Cardiac‡  5   37   1.3  
Inflammatory bowel disease   1   31   1.3  
Diabetes   3   50   1.6  
Cerebrovascular disease   < 1   67   1.6  
Psychiatric disturbance†  9   29   1.8  
Hepatic, mild‡  16   30   1.9  
Obesity†  2   33   1.9  
Infection†  4   40   1.9  
Rheumatologic   4   45   2.3  
Peptic ulcer   1   38   2.5  
Renal, moderate/severe‡  2   42   2.6  
Pulmonary, moderate‡  24   36   3.0  
Prior solid tumor‡  2   38   3.1  
Heart valve disease   2   33   3.3  
Pulmonary, severe‡  9   39   3.7  
Hepatic, moderate/severe‡  4   43   3.9  
Peripheral vascular disease
 		 0
 		 —
 		 —
 

— indicates not applicable.

*

Adjusted for all other comorbidities, age, high disease risk, and conditioning type.

†

Newly investigated comorbidities.

‡

Comorbidities with modified definitions compared with the original CCI.

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