Examples of a comparison of LGL-associated clonotypes based on the physicochemical AA properties (8-AA substitution)
Patient . | VB-JB . | CDR3/20AA code . | . | CDR3/8AA substitution . | . | ||
|---|---|---|---|---|---|---|---|
| 53 | VB18-JB2.7 | ASS-PPVGDR | -SYEQYF | BEE-BBBDGH | -EAGEAA | ||
| 4 | VB17-JB2.3 | ASS-IAVRLA | -STDTQYF | BEE-BBBHBB | -EEGEEAA | ||
| 50 | VB13-JB2.7 | ASS-VPGG | -EQYF | BEE-BBDD | -GEAA | ||
| 54 | VB13-JB2.7 | ASS-VPGG | -EQYF | BEE-BBDD | -GEAA | ||
| 18 | VB3-JB2.1 | ASS-PLGAGV | -YNEQFF | BEE-BBDBDB | -AEGEAA | ||
| 27 | VB18-JB2.7 | ASS-PAGGSG | -SYEQYF | BEE-BBD DED | -EAGEAA | ||
| 12 | VB14-JB2.7 | ASS-LLTKTG | -SYEQYF | BEE-BBEHED | -EAGEAA | ||
| 29 | VB5-JB2.7 | ASS-PLRG | -SYEQYF | BEE-BB H D | -EAGEAA | ||
| 55 | VB18-JB2.5 | ASS-PNI | -ETQY | BEE-BEB | -GEEA | ||
| 19 | VB2-JB2.3 | ASS-PTLRDRGR | -TDTQYF | BEE-BEBHGHDH | -EGEEAA | ||
| 46 | VB17-JB2.1 | ASS-TFG | -EQFF | BEE-EAD | -GEAA | ||
| 44 | VB21-JB1.1 | ASS-SY | -NEAFF | BEE-EA | -EGBAA | ||
Patient . | VB-JB . | CDR3/20AA code . | . | CDR3/8AA substitution . | . | ||
|---|---|---|---|---|---|---|---|
| 53 | VB18-JB2.7 | ASS-PPVGDR | -SYEQYF | BEE-BBBDGH | -EAGEAA | ||
| 4 | VB17-JB2.3 | ASS-IAVRLA | -STDTQYF | BEE-BBBHBB | -EEGEEAA | ||
| 50 | VB13-JB2.7 | ASS-VPGG | -EQYF | BEE-BBDD | -GEAA | ||
| 54 | VB13-JB2.7 | ASS-VPGG | -EQYF | BEE-BBDD | -GEAA | ||
| 18 | VB3-JB2.1 | ASS-PLGAGV | -YNEQFF | BEE-BBDBDB | -AEGEAA | ||
| 27 | VB18-JB2.7 | ASS-PAGGSG | -SYEQYF | BEE-BBD DED | -EAGEAA | ||
| 12 | VB14-JB2.7 | ASS-LLTKTG | -SYEQYF | BEE-BBEHED | -EAGEAA | ||
| 29 | VB5-JB2.7 | ASS-PLRG | -SYEQYF | BEE-BB H D | -EAGEAA | ||
| 55 | VB18-JB2.5 | ASS-PNI | -ETQY | BEE-BEB | -GEEA | ||
| 19 | VB2-JB2.3 | ASS-PTLRDRGR | -TDTQYF | BEE-BEBHGHDH | -EGEEAA | ||
| 46 | VB17-JB2.1 | ASS-TFG | -EQFF | BEE-EAD | -GEAA | ||
| 44 | VB21-JB1.1 | ASS-SY | -NEAFF | BEE-EA | -EGBAA | ||
A redundant classification scheme was applied for the comparison of the TCR-CDR3 region, based on the structural, chemical, charge, and functional properties of the amino acids. For substitution code, see “Sequence analysis.”
VB-JB indicates VB and JB regions used by the immunodominant clonotype; CDR3/20AA code and CDR3/8AA, CDR3 region sequence in 20-AA and 8-AA code, respectively; and Jun, invariant amino acids of the JB region. Italic amino acids indicate the beginning of the JB region and include the invariant JB-specific amino acids. Underlined type indicates AA differences.