Definition of clinicohematologic response
Response type . | Definition . |
|---|---|
| Complete response | Complete response in all the criteria |
| Major response | Provided that the criteria for complete response are not satisfied: |
| 1. Any response in anemia and splenomegaly without progression in constitutional symptoms, OR | |
| 2. Complete response in anemia, or partial response in anemia that is transfusion dependent, and response in constitutional symptoms without progression in splenomegaly, OR | |
| 3. Any response in splenomegaly and response in constitutional symptoms without progression in anemia | |
| Moderate response | Provided that the criteria for major response are not satisfied: |
| 1. Complete response in anemia with progression in splenomegaly, OR | |
| 2. Partial response in anemia without progression in splenomegaly, OR | |
| 3. Any response in splenomegaly without progression in anemia and constitutional symptoms | |
| Minor response | Provided that the criteria for moderate response are not satisfied: |
| Any response in WBC or platelet count without progression in anemia, splenomegaly, or constitutional symptoms | |
| No response | Any response that does not satisfy minor response |
Response type . | Definition . |
|---|---|
| Complete response | Complete response in all the criteria |
| Major response | Provided that the criteria for complete response are not satisfied: |
| 1. Any response in anemia and splenomegaly without progression in constitutional symptoms, OR | |
| 2. Complete response in anemia, or partial response in anemia that is transfusion dependent, and response in constitutional symptoms without progression in splenomegaly, OR | |
| 3. Any response in splenomegaly and response in constitutional symptoms without progression in anemia | |
| Moderate response | Provided that the criteria for major response are not satisfied: |
| 1. Complete response in anemia with progression in splenomegaly, OR | |
| 2. Partial response in anemia without progression in splenomegaly, OR | |
| 3. Any response in splenomegaly without progression in anemia and constitutional symptoms | |
| Minor response | Provided that the criteria for moderate response are not satisfied: |
| Any response in WBC or platelet count without progression in anemia, splenomegaly, or constitutional symptoms | |
| No response | Any response that does not satisfy minor response |