Definition of response for each core clinicohematologic criterion
Criterion . | Complete response . | Partial response . | Progression . |
|---|---|---|---|
| Hemoglobin (Hb) level | Hb ≥ 120 g/L for patients with Hb < 100 g/L; or achievement of transfusion independence, with stable Hb > 110 g/L, for RBC transfusion-dependent patients | Increase of Hb ≥ 20 g/L (but Hb < 120 g/L) for non-RBC transfusion-dependent patients; or reduction ≥ 50% of transfusion requirement for RBC transfusion-dependent patients | Decrease of Hb ≥ 20 g/L or transfusion requirement for non-RBC transfusion-dependent patients; or increase ≥ 50% of transfusion requirement for RBC transfusion-dependent patients |
| Splenomegaly* | Spleen not palpable | Decrease of spleen size ≥ 50% in patients with spleen size ≤ 10 cm from the left costal margin; or decrease of spleen size ≥ 30% in patients with spleen size > 10 cm from the left costal margin | Increase of spleen size ≥ 50% in patients with spleen size ≤ 10 cm from the left costal margin; or increase of spleen size ≥ 30% in patients with spleen size > 10 cm from the left costal margin |
| Constitutional symptoms† | Absence of constitutional symptoms | n/a | Appearance of constitutional symptoms |
| Platelet (PTL) count | PTL count 150 × 109/L to 400 × 109/L | Decrease of PTL count ≥ 50% without normalization in patients with PTL count > 800 × 109/L; or increase of PTL count ≥ 50 × 109/L without normalization for patients with PTL count < 100 × 109/L | n/a |
| White blood cell (WBC) count | WBC count 4 × 109/L to 10 × 109/L | Decrease of WBC count ≥ 50% without normalization in patients with WBC count > 20 × 109/L; or increase of WBC count ≥ 1 × 109/L without normalization in patients with WBC count < 4 × 109/L | n/a |
Criterion . | Complete response . | Partial response . | Progression . |
|---|---|---|---|
| Hemoglobin (Hb) level | Hb ≥ 120 g/L for patients with Hb < 100 g/L; or achievement of transfusion independence, with stable Hb > 110 g/L, for RBC transfusion-dependent patients | Increase of Hb ≥ 20 g/L (but Hb < 120 g/L) for non-RBC transfusion-dependent patients; or reduction ≥ 50% of transfusion requirement for RBC transfusion-dependent patients | Decrease of Hb ≥ 20 g/L or transfusion requirement for non-RBC transfusion-dependent patients; or increase ≥ 50% of transfusion requirement for RBC transfusion-dependent patients |
| Splenomegaly* | Spleen not palpable | Decrease of spleen size ≥ 50% in patients with spleen size ≤ 10 cm from the left costal margin; or decrease of spleen size ≥ 30% in patients with spleen size > 10 cm from the left costal margin | Increase of spleen size ≥ 50% in patients with spleen size ≤ 10 cm from the left costal margin; or increase of spleen size ≥ 30% in patients with spleen size > 10 cm from the left costal margin |
| Constitutional symptoms† | Absence of constitutional symptoms | n/a | Appearance of constitutional symptoms |
| Platelet (PTL) count | PTL count 150 × 109/L to 400 × 109/L | Decrease of PTL count ≥ 50% without normalization in patients with PTL count > 800 × 109/L; or increase of PTL count ≥ 50 × 109/L without normalization for patients with PTL count < 100 × 109/L | n/a |
| White blood cell (WBC) count | WBC count 4 × 109/L to 10 × 109/L | Decrease of WBC count ≥ 50% without normalization in patients with WBC count > 20 × 109/L; or increase of WBC count ≥ 1 × 109/L without normalization in patients with WBC count < 4 × 109/L | n/a |