Adverse reactions observed at least 4 patients
. | No. patients (%) . | . | . | ||
|---|---|---|---|---|---|
| Adverse reaction . | Total . | Mild . | Moderate . | ||
| Common cold | 16 (57.1) | 0 (0) | 16 (57.1) | ||
| Pruritus | 6 (21.4) | 3 (10.7) | 3 (10.7) | ||
| Malaise | 6 (21.4) | 4 (14.3) | 2 (7.1) | ||
| Pharyngitis | 5 (17.9) | 0 (0) | 5 (17.9) | ||
| Diarrhea | 5 (17.9) | 2 (7.1) | 3 (10.7) | ||
| Rash | 5 (17.9) | 2 (7.1) | 3 (10.7) | ||
| Eczema | 5 (17.9) | 0 (0) | 5 (17.9) | ||
| Low-grade fever | 5 (17.9) | 3 (10.7) | 2 (7.1) | ||
| Urinary tract infection | 4 (14.3) | 0 (0) | 4 (14.3) | ||
| Chest pain | 4 (14.3) | 3 (10.7) | 1 (3.6) | ||
| Aphthous stomatitis | 4 (14.3) | 0 (0) | 4 (14.3) | ||
. | No. patients (%) . | . | . | ||
|---|---|---|---|---|---|
| Adverse reaction . | Total . | Mild . | Moderate . | ||
| Common cold | 16 (57.1) | 0 (0) | 16 (57.1) | ||
| Pruritus | 6 (21.4) | 3 (10.7) | 3 (10.7) | ||
| Malaise | 6 (21.4) | 4 (14.3) | 2 (7.1) | ||
| Pharyngitis | 5 (17.9) | 0 (0) | 5 (17.9) | ||
| Diarrhea | 5 (17.9) | 2 (7.1) | 3 (10.7) | ||
| Rash | 5 (17.9) | 2 (7.1) | 3 (10.7) | ||
| Eczema | 5 (17.9) | 0 (0) | 5 (17.9) | ||
| Low-grade fever | 5 (17.9) | 3 (10.7) | 2 (7.1) | ||
| Urinary tract infection | 4 (14.3) | 0 (0) | 4 (14.3) | ||
| Chest pain | 4 (14.3) | 3 (10.7) | 1 (3.6) | ||
| Aphthous stomatitis | 4 (14.3) | 0 (0) | 4 (14.3) | ||
Twenty-eight patients were enrolled in this study. The severity of an adverse reaction was graded as mild (the event did not interfere with the patient's usual activity), moderate (the event interfered with the patient's usual activity), or severe (the event prevented the patient from undertaking some usual activity and necessitated therapeutic cessation of the study drug).