Baseline demographic and clinical characteristics
. | . | . | . | . | Laboratory data at baseline . | . | . | . | . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient . | Sex . | Age at entry into trial, y . | Duration of disease, y . | Histologic diagnosis . | CRP, mg/L . | IgG, g/L . | Hb, g/L . | Alb, g/L . | T-cho, mg/dL . | HHV-8 . | IL-6, pg/mL* . | Manifestation/complication . | ||||||
| 1 | F | 33 | 9 | PC | 100 | 41.0 | 77 | 27 | 52 | + | 31.9 | Splenomegaly, skin disorder | ||||||
| 2 | F | 36 | 4 | PC | 122 | 48.8 | 68 | 28 | 89 | - | 56.2 | Splenomegaly, hepatomegaly, LIP, skin disorder | ||||||
| 3 | M | 64 | 1 | PC | 24 | 58.9 | 113 | 29 | 148 | - | 7.5 | Splenomegaly, LIP | ||||||
| 4 | M | 53 | 11 | PC | 92 | 48.5 | 102 | 24 | 89 | - | 25.2 | LIP, skin disorder | ||||||
| 5 | M | 37 | 1 | PC | 70 | 39.9 | 126 | 34 | 131 | - | 16.5 | LIP | ||||||
| 6 | M | 66 | 2 | PC | 24 | 11.5 | 113 | 34 | 231 | - | 15.9 | Skin disorder, CMMoL | ||||||
| 7 | M | 23 | 3 | PC | 135 | 48.3 | 101 | 23 | 116 | - | 36.8 | Skin disorder | ||||||
| 8 | M | 55 | 11 | PC | 110 | 42.6 | 108 | 31 | 91 | - | 30.6 | Splenomegaly, hepatomegaly | ||||||
| 9 | F | 27 | 2 | PC | 136 | 73.7 | 93 | 30 | 94 | - | 44.8 | Splenomegaly, hepatomegaly, LIP, skin disorder | ||||||
| 10 | F | 37 | 5 | PC | 89 | 33.6 | 115 | 31 | 169 | - | 10.7 | Splenomegaly, LIP | ||||||
| 11 | F | 51 | 9 | PC | 50 | 102.0 | 73 | 17 | 80 | - | 21.4 | None | ||||||
| 12 | M | 27 | 3 | PC | 107 | 74.0 | 112 | 26 | 97 | - | 19.8 | LIP | ||||||
| 13 | F | 50 | 14 | PC | 215 | 66.5 | 59 | 21 | 101 | - | 90.6 | Splenomegaly, hepatomegaly, LIP | ||||||
| 14 | F | 35 | 14 | PC | 27 | 24.6 | 112 | 36 | 144 | - | 7.0 | Splenomegaly, skin disorder | ||||||
| 15 | M | 60 | 4 | PC | 24 | 65.2 | 72 | 32 | 85 | - | 5.9 | LIP | ||||||
| 16 | F | 53 | 3 | PC | 104 | 48.8 | 71 | 22 | 111 | - | 35.8 | LIP | ||||||
| 17 | M | 49 | 4 | PC | 120 | 58.5 | 99 | 25 | 117 | - | 86.9 | Skin disorder | ||||||
| 18 | M | 32 | 16 | PC | 62 | 66.4 | 111 | 26 | 103 | - | 16.9 | LIP | ||||||
| 19 | F | 37 | 23 | PC | 175 | 65.1 | 65 | 17 | 77 | - | 60.2 | Splenomegaly, skin disorder | ||||||
| 20 | M | 57 | 2 | PC | 48 | 40.3 | 116 | 28 | 138 | - | 16.2 | LIP | ||||||
| 21 | M | 63 | 7 | PC | 29 | 27.9 | 96 | 25 | 165 | - | 18.8 | Splenomegaly, LIP, skin disorder, SA | ||||||
| 22 | F | 27 | 3 | PC | 53 | 41.2 | 99 | 30 | 129 | - | 7.3 | LIP, skin disorder | ||||||
| 23 | M | 39 | 5 | PC | 108 | 50.7 | 51 | 34 | 119 | - | 170.0 | LIP | ||||||
| 24 | M | 38 | 5 | PC | 117 | 60.6 | 94 | 27 | 106 | - | 44.7 | None | ||||||
| 25 | M | 49 | 5 | PC | 127 | 84.7 | 62 | 20 | 77 | + | 28.7 | LIP | ||||||
| 26 | M | 36 | 3 | PC | 25 | 42.0 | 137 | 36 | 125 | - | 10.5 | Splenomegaly, hepatomegaly, LIP | ||||||
| 27 | M | 37 | 4 | PC | 31 | 28.3 | 68 | 25 | 88 | - | 15.5 | LIP, skin disorder, SA | ||||||
| 28 | F | 43 | 3 | PC | 114 | 68.0 | 72 | 23 | 118 | - | 42.7 | None | ||||||
. | . | . | . | . | Laboratory data at baseline . | . | . | . | . | . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient . | Sex . | Age at entry into trial, y . | Duration of disease, y . | Histologic diagnosis . | CRP, mg/L . | IgG, g/L . | Hb, g/L . | Alb, g/L . | T-cho, mg/dL . | HHV-8 . | IL-6, pg/mL* . | Manifestation/complication . | ||||||
| 1 | F | 33 | 9 | PC | 100 | 41.0 | 77 | 27 | 52 | + | 31.9 | Splenomegaly, skin disorder | ||||||
| 2 | F | 36 | 4 | PC | 122 | 48.8 | 68 | 28 | 89 | - | 56.2 | Splenomegaly, hepatomegaly, LIP, skin disorder | ||||||
| 3 | M | 64 | 1 | PC | 24 | 58.9 | 113 | 29 | 148 | - | 7.5 | Splenomegaly, LIP | ||||||
| 4 | M | 53 | 11 | PC | 92 | 48.5 | 102 | 24 | 89 | - | 25.2 | LIP, skin disorder | ||||||
| 5 | M | 37 | 1 | PC | 70 | 39.9 | 126 | 34 | 131 | - | 16.5 | LIP | ||||||
| 6 | M | 66 | 2 | PC | 24 | 11.5 | 113 | 34 | 231 | - | 15.9 | Skin disorder, CMMoL | ||||||
| 7 | M | 23 | 3 | PC | 135 | 48.3 | 101 | 23 | 116 | - | 36.8 | Skin disorder | ||||||
| 8 | M | 55 | 11 | PC | 110 | 42.6 | 108 | 31 | 91 | - | 30.6 | Splenomegaly, hepatomegaly | ||||||
| 9 | F | 27 | 2 | PC | 136 | 73.7 | 93 | 30 | 94 | - | 44.8 | Splenomegaly, hepatomegaly, LIP, skin disorder | ||||||
| 10 | F | 37 | 5 | PC | 89 | 33.6 | 115 | 31 | 169 | - | 10.7 | Splenomegaly, LIP | ||||||
| 11 | F | 51 | 9 | PC | 50 | 102.0 | 73 | 17 | 80 | - | 21.4 | None | ||||||
| 12 | M | 27 | 3 | PC | 107 | 74.0 | 112 | 26 | 97 | - | 19.8 | LIP | ||||||
| 13 | F | 50 | 14 | PC | 215 | 66.5 | 59 | 21 | 101 | - | 90.6 | Splenomegaly, hepatomegaly, LIP | ||||||
| 14 | F | 35 | 14 | PC | 27 | 24.6 | 112 | 36 | 144 | - | 7.0 | Splenomegaly, skin disorder | ||||||
| 15 | M | 60 | 4 | PC | 24 | 65.2 | 72 | 32 | 85 | - | 5.9 | LIP | ||||||
| 16 | F | 53 | 3 | PC | 104 | 48.8 | 71 | 22 | 111 | - | 35.8 | LIP | ||||||
| 17 | M | 49 | 4 | PC | 120 | 58.5 | 99 | 25 | 117 | - | 86.9 | Skin disorder | ||||||
| 18 | M | 32 | 16 | PC | 62 | 66.4 | 111 | 26 | 103 | - | 16.9 | LIP | ||||||
| 19 | F | 37 | 23 | PC | 175 | 65.1 | 65 | 17 | 77 | - | 60.2 | Splenomegaly, skin disorder | ||||||
| 20 | M | 57 | 2 | PC | 48 | 40.3 | 116 | 28 | 138 | - | 16.2 | LIP | ||||||
| 21 | M | 63 | 7 | PC | 29 | 27.9 | 96 | 25 | 165 | - | 18.8 | Splenomegaly, LIP, skin disorder, SA | ||||||
| 22 | F | 27 | 3 | PC | 53 | 41.2 | 99 | 30 | 129 | - | 7.3 | LIP, skin disorder | ||||||
| 23 | M | 39 | 5 | PC | 108 | 50.7 | 51 | 34 | 119 | - | 170.0 | LIP | ||||||
| 24 | M | 38 | 5 | PC | 117 | 60.6 | 94 | 27 | 106 | - | 44.7 | None | ||||||
| 25 | M | 49 | 5 | PC | 127 | 84.7 | 62 | 20 | 77 | + | 28.7 | LIP | ||||||
| 26 | M | 36 | 3 | PC | 25 | 42.0 | 137 | 36 | 125 | - | 10.5 | Splenomegaly, hepatomegaly, LIP | ||||||
| 27 | M | 37 | 4 | PC | 31 | 28.3 | 68 | 25 | 88 | - | 15.5 | LIP, skin disorder, SA | ||||||
| 28 | F | 43 | 3 | PC | 114 | 68.0 | 72 | 23 | 118 | - | 42.7 | None | ||||||
To convert total cholesterol from milligrams per deciliter to millimoles per liter, multiply milligrams per deciliter by 0.02586.
T-cho indicates total cholesterol; F, female; M, male; PC, plasma-cell type; LIP, lymphocytic interstitial pneumonia; SA, secondary amyloidosis.
Normal range of serum IL-6 is less than 4 pg/mL.