Abnormal iron distribution in Irp2−/−versus wild-type mice
. | +/+ (n) . | −/− (n) . |
|---|---|---|
| Liver | 195 ± 9 (27) | 300 ± 15 (24)* |
| Duodenum | 571 ± 41 (17) | 1058 ± 113 (13)* |
| Spleen | 2191 ± 191 (15) | 1331 ± 122 (11)* |
| Brain | 157 ± 11 (18) | 148 ± 13 (14) |
. | +/+ (n) . | −/− (n) . |
|---|---|---|
| Liver | 195 ± 9 (27) | 300 ± 15 (24)* |
| Duodenum | 571 ± 41 (17) | 1058 ± 113 (13)* |
| Spleen | 2191 ± 191 (15) | 1331 ± 122 (11)* |
| Brain | 157 ± 11 (18) | 148 ± 13 (14) |
Tissue nonheme iron content was determined using the bathophenantroline chromogen20 in 8- to 10-week-old mice and is given in milligram per gram of dried tissue. Results are presented as means ± standard error. The sample size (n) is indicated.
P = .001, Student t test.