The genotype of activating KIR and of HLA-C in PNH patients
Patient no. . | Activating KIR genotype . | HLA-C allele . |
|---|---|---|
| PNH1 | 2DS4 | 04,‡16 |
| PNH2 | 2DS4 | 04,‡07 |
| PNH3 | 2DS2,†2DS4 | 08,†12 |
| PNH4 | 2DS1,*2DS2, 2DS3, 2DS4,‡2DS5, 3DS1 | 04,‡06 |
| PNH5 | 2DS1,*2DS2,†2DS3, 3DS1 | 04,*07† |
| PNH6 | 2DS1,*2DS3, 2DS4, 3DS1 | 05,*15 |
| PNH7 | 2DS2,†2DS3, 2DS4 | 01,†07† |
| PNH9 | 2DS1,*2DS2,†2DS3, 2DS4, 2DS5, 3DS1 | 06,*07† |
| PNH11 | 2DS4 | 07, 07 |
| PNH12 | 2DS4‡ | 03, 04‡ |
| PNH13 | 2DS4 | 06, 15 |
Patient no. . | Activating KIR genotype . | HLA-C allele . |
|---|---|---|
| PNH1 | 2DS4 | 04,‡16 |
| PNH2 | 2DS4 | 04,‡07 |
| PNH3 | 2DS2,†2DS4 | 08,†12 |
| PNH4 | 2DS1,*2DS2, 2DS3, 2DS4,‡2DS5, 3DS1 | 04,‡06 |
| PNH5 | 2DS1,*2DS2,†2DS3, 3DS1 | 04,*07† |
| PNH6 | 2DS1,*2DS3, 2DS4, 3DS1 | 05,*15 |
| PNH7 | 2DS2,†2DS3, 2DS4 | 01,†07† |
| PNH9 | 2DS1,*2DS2,†2DS3, 2DS4, 2DS5, 3DS1 | 06,*07† |
| PNH11 | 2DS4 | 07, 07 |
| PNH12 | 2DS4‡ | 03, 04‡ |
| PNH13 | 2DS4 | 06, 15 |
Patients as in Table 1. The ligands of KIR2DS1 are the HLA-CLys80 (w2, w4, w5, w6); the ligands of KIR2DS2 are the HLA-CAsn80 (w1, w3, w7, w8); the ligand of KIR2DS4 is the HLA-Cw4; the ligands of KIR2DS3 and KIR2DS5 are still unknown.
Positive matches for KIRDS1
Matches for KIR2DS2
Matches for KIRDS415-17,45,46