Table 1. Clinical and hematologic... | American Society of Hematology

Table 1.

Clinical and hematologic features of patients investigated

									Size of PNH-cell population^*
Patients with PNH	Sex/age, y	Time since diagnosis, y	Hb, g/L	WBC, x10^–9/L	ANC, x10^–9/L	Lymph, x10^–9/L	Platelets, x10^–9/L	Retics, %	RBCs, %	PMN, %	Hemoglobinuria	Thrombosis	Blood transfusion	Other treatment
1	M/53	1	102	4.4	3.2	0.9	249	6.0	21	81	Yes	No	Occasional	Supportive
2	M/45	2	94	2.9	1.6	1.1	97	4.8	20	55	Yes	No	Never	Supportive
3	M/34	2	101	4.7	2.5	1.7	178	10.2	50	80	Yes	No	Occasional	Supportive†
4	F/54	10	81	3.3	2.4	0.7	57	7.1	36	98	Yes	Hepato-portal	Never	Supportive
5	F/54	10	77	3.8	1.8	1.5	193	6.4	30	93	Yes	No‡	Never	Supportive
6	M/33	5	123	2.1	0.9	0.9	87	2.2	22	69	Yes	No	Never	Supportive
7	F/25	8	67	2.5	1.1	1.2	83	14.5	23	82	Yes	No	Regular	Supportive§
8	F/53	7	121	3.6	1.6	1.7	64	2.1	51	96	Yes	Budd-Chiari	Occasional	Supportive
9	F/25	1	109	4.5	2.4	1.8	323	9.8	26	80	Yes	No‡	Never	Supportive
10	F/45	5	86	8.7	7.5	1.0	143	17.0	75	99	Yes	No	Occasional	Supportive
11	M/33	5	101	5.6	3.3	1.8	262	6.8	37	97	Yes	No	Occasional	Supportive§
12	F/55	23	84	3.9	2.5	1.0	185	10.1	54	90	Yes	No	Regular	Supportive
13	F/32	3	78	4.0	2.2	1.3	193	2.4	91	69	Yes	No	Occasional	Supportive§

									Size of PNH-cell population^*
Patients with PNH	Sex/age, y	Time since diagnosis, y	Hb, g/L	WBC, x10^–9/L	ANC, x10^–9/L	Lymph, x10^–9/L	Platelets, x10^–9/L	Retics, %	RBCs, %	PMN, %	Hemoglobinuria	Thrombosis	Blood transfusion	Other treatment
1	M/53	1	102	4.4	3.2	0.9	249	6.0	21	81	Yes	No	Occasional	Supportive
2	M/45	2	94	2.9	1.6	1.1	97	4.8	20	55	Yes	No	Never	Supportive
3	M/34	2	101	4.7	2.5	1.7	178	10.2	50	80	Yes	No	Occasional	Supportive†
4	F/54	10	81	3.3	2.4	0.7	57	7.1	36	98	Yes	Hepato-portal	Never	Supportive
5	F/54	10	77	3.8	1.8	1.5	193	6.4	30	93	Yes	No‡	Never	Supportive
6	M/33	5	123	2.1	0.9	0.9	87	2.2	22	69	Yes	No	Never	Supportive
7	F/25	8	67	2.5	1.1	1.2	83	14.5	23	82	Yes	No	Regular	Supportive§
8	F/53	7	121	3.6	1.6	1.7	64	2.1	51	96	Yes	Budd-Chiari	Occasional	Supportive
9	F/25	1	109	4.5	2.4	1.8	323	9.8	26	80	Yes	No‡	Never	Supportive
10	F/45	5	86	8.7	7.5	1.0	143	17.0	75	99	Yes	No	Occasional	Supportive
11	M/33	5	101	5.6	3.3	1.8	262	6.8	37	97	Yes	No	Occasional	Supportive§
12	F/55	23	84	3.9	2.5	1.0	185	10.1	54	90	Yes	No	Regular	Supportive
13	F/32	3	78	4.0	2.2	1.3	193	2.4	91	69	Yes	No	Occasional	Supportive§

Hb indicates hemoglobin; PMN, granulocytes; Lymph, lymphocytes; Retics, reticulocytes; RBCs, red blood cells; Yes, recurrent episodes of macroscopic hemoglobinuria throughout several years of clinical history.

PMN reflects the relative size of the PNH-cell population more accurately than the percentage of PNH RBCs, because the latter will be grossly underestimated as a consequence of selective hemolysis; this may be further complicated by blood transfusion

†

Previous prednisone treatment

‡

Recurrent attacks of severe abdominal pain but no documented thrombosis

Previous antithymocyte globulin treatment

View Large

This Feature Is Available To Subscribers Only