Multivariate analyses of CR rate, event-free survival, and overall survival in 309 elderly patients with AML using treatment arm, IPS, and treatment arm by IPS interaction as covariates
. | CR rate . | . | . | Event-free survival . | . | . | Overall survival . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable . | OR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | ||||||
| PSC-833 arm | 1.49 | 0.71-3.15 | .29 | 1.16 | 0.78-1.71 | .46 | 0.96 | 0.65-1.44 | .86 | ||||||
| IPS* | 0.75 | 0.54-1.03 | .07 | 1.19 | 1.01-1.40 | .04 | 1.12 | 0.95-1.32 | .17 | ||||||
| PSC-833 arm × IPS | 1.05 | 0.68-1.63 | .84 | 0.94 | 0.75-1.17 | .57 | 1.06 | 0.85-1.33 | .61 | ||||||
. | CR rate . | . | . | Event-free survival . | . | . | Overall survival . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable . | OR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | ||||||
| PSC-833 arm | 1.49 | 0.71-3.15 | .29 | 1.16 | 0.78-1.71 | .46 | 0.96 | 0.65-1.44 | .86 | ||||||
| IPS* | 0.75 | 0.54-1.03 | .07 | 1.19 | 1.01-1.40 | .04 | 1.12 | 0.95-1.32 | .17 | ||||||
| PSC-833 arm × IPS | 1.05 | 0.68-1.63 | .84 | 0.94 | 0.75-1.17 | .57 | 1.06 | 0.85-1.33 | .61 | ||||||
PSC-833 arm × IPS indicates the interaction term between these 2 variables.
IPS was coded as 0, negative; 1, low-positive; 2, intermediate-positive; 3, high-positive.