Table 3.

Changes in transfusion requirements during eculizumab treatment



Transfusion rates
Before study*
12 wk
64 wk
Patient group
Mean
Median
Mean
Median
Mean
Median
P
All patients   2.1   1.8   0.6   0.0   0.5   0.3   .001  
Patients without cytopenia  2.4   2.0   0.2   0.0   0.2   0.1   -  
Patients with cytopenia§
 
1.8
 
1.8
 
1.2
 
0.7
 
0.8
 
0.7
 
-
 


Transfusion rates
Before study*
12 wk
64 wk
Patient group
Mean
Median
Mean
Median
Mean
Median
P
All patients   2.1   1.8   0.6   0.0   0.5   0.3   .001  
Patients without cytopenia  2.4   2.0   0.2   0.0   0.2   0.1   -  
Patients with cytopenia§
 
1.8
 
1.8
 
1.2
 
0.7
 
0.8
 
0.7
 
-
 

Transfusion rates are units per patient per month.

- indicates not determined.

*

Values during 52-week period before treatment.

Comparisons of median change from before study to the 64-week treatment period.

Platelet count ≥ 150 × 109/L; n = 6.

§

Platelet count < 150 × 109/L; n = 5.

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