Integrations at genes identified in MSCV-Sox4 virus-induced leukemias
Tumor no., gene . | Protein family . | Location and distance . | Orientation . | Mouse chromosome . | Human chromosome . | Accession no. . |
|---|---|---|---|---|---|---|
| 0137 | ||||||
| Mef2c* | Transcription factor | Intron 3 | Same | 13 | 5q14 | AK_009139 |
| EKI | Ethanolamine kinase | 5′, 10.5 kb | Same | 6 | 12p12.2 | AK_044502 |
| BC060648 | Enzyme | 5′, 0.5 kb | Same | 4 | ND | BC_060648 |
| Arhh | GTPase | 5′, 2.2 kb | Same | 5 | 4p13 | AK_017885 |
| AK016052 | ND | Intron 5 | Same | 17 | ND | AK_016052 |
| AF397014 | ND | Intron 11 | Inverse | 13 | ND | AF_397014 |
| 0841 | ||||||
| Sfpi 1* | Transcription factor | Intron 1 | Same | 2 | 11p11.2 | BC003815 |
| CB520747 | ND | Intron 6 | Inverse | 4 | ND | CB_520747 |
| Cish | Signal transduction | Intron 1 | Same | 9 | 3p21.3 | BC_003783 |
| Wrnip1 | Helicase | 3′, 10 kb | Same | 13 | 6p25.2 | AK_050368 |
| Ifitm31 | Transmembrane protein | 5′, 11 kb | Inverse | 7 | ND | BC_002160 |
| Tde1 | Membrane protein | Intron 1 | Inverse | 2 | 20q13.1-13.3 | AK_031101 |
| 0935 | ||||||
| Hcph* | Tyrosine phosphatase | Intron 3 | Inverse | 6 | 12p13 | BC_012660 |
| 1494 | ||||||
| Rnf8 | Ring finger protein | Intron 1 | Inverse | 17 | ND | AJ_242721 |
| Rnf11 | Ring finger protein | Intron 1 | Same | 4 | 1pter-p22.1 | BC_010299 |
| Golga5 | Golgi protein | 3′, 24 kb | Same | 12 | 14q32.12-32.13 | BC_016883 |
| AK042193 | ND | exon 2 | Same | 1 | ND | AK_042193 |
| 1668 | ||||||
| AK054410 | ND | Intron 20 | Same | 9 | ND | AK_054410 |
| Soat1 | Sterol O-acyltransferase | Intron 1 | Same | 1 | 1q25 | L_42293 |
| AK017935 | ND | 5′, 17 kb | Inverse | 19 | ND | AK_017935 |
| 1865 | ||||||
| Plekha2* | pH domain | Intron 1 | Same | 8 | 8p11 | BC_010215 |
| Scm14 | Polycomb protein | Intron 1 | Inverse | 10 | ND | BC_043310 |
| Aif1 | Calcium binding | 5′, 0.5 kb | Inverse | 17 | 6p21.3 | AK_006184 |
| AK089567 | ND | 5′, 2 kb | Inverse | ND | ND | AK_089567 |
| Nfat5* | Transcription factor | 5′, 40 kb | Inverse | 8 | 16q22.1 | AF_200687 |
| 2208 | ||||||
| Elf4* | Transcription factor | 5′, 7 kb | Inverse | X | Xq26 | AF_016714 |
| Kif21b | Cytoskeleton binding | Intron 1 | Inverse | 1 | ND | AF_202893 |
| Runx1* | Transcription factor | Intron 1 | Inverse | 16 | 21q22.3 | AK_051758 |
| AU043488 | ND | Intron 1 | Inverse | 10 | ND | AU_043488 |
| 2938 | ||||||
| AK129203* | EST1 telomerase binding | Intron 7 | Inverse | 11 | ND | AK_129203 |
| Selp1 | Selectin ligand | 3′, 6 kb | Inverse | 5 | 12q24 | AK_089214 |
| AK039624 | ND | 5′, 66 kb | Inverse | 8 | ND | AK_039624 |
| 2987 | ||||||
| Dusp2 | Phosphatase | 5′, 14 kb | Same | 2 | 2q11 | L_11330 |
| AK016300 | tRNA deacylase | Intron 2 | Same | 12 | ND | AK_016300 |
| Irak3 | Signal transduction | Intron 1 | Same | 10 | 12q14.2 | AK_029057 |
| Ern1 | Signaling | Intron 1 | Inverse | 11 | 16p12 | AB_031332 |
| AK020256 | ND | Intron 1 | Inverse | 10 | ND | AK_020256 |
| 4564 | ||||||
| Cgef | GEF | Intron 3 | Inverse | 2 | 2q31-32 | AB_021132 |
| Nrf1 | Transcription factor | 5′, 2 kb | Inverse | 6 | 7q32 | AK_037697 |
| 0249 | ||||||
| Mef2o* | Transcription factor | Intron 3 | Same | 13 | 5q14 | AK_009139 |
| Hspa9a* | Heat shock protein | 5′, 0.7 kb | Inverse | 18 | 5q31.1 | D_17556 |
| BC042709 | ND | 5′, 26 kb | Same | 4 | ND | BC_042709 |
| 5413 | ||||||
| Sfpi1* | Transcription factor | Intron 1 | Same | 2 | 11p11.2 | BC_003815 |
| AK014882 | ND | 5′, 81 kb | Same | 10 | ND | AK_014882 |
| Tuba4 | Cytoskeleton | Intron 1 | Same | 1 | ND | BC_019959 |
| Vdac2 | Anion channel | Intron 2 | Inverse | 14 | 10q22 | U_30838 |
| BC042901 | ND | Exon 9 | Same | 7 | ND | BC_042901 |
| 6577 | ||||||
| Sfpi1* | Transcription factor | Intron 1 | Inverse | 2 | 11p11.2 | BC_003815 |
| AK008545 | ND | 3′, 4 kb | Same | X | ND | AK_008545 |
| Sbf1 | Antiphosphatase | Intron 1 | Same | 15 | ND | AK_129485 |
Tumor no., gene . | Protein family . | Location and distance . | Orientation . | Mouse chromosome . | Human chromosome . | Accession no. . |
|---|---|---|---|---|---|---|
| 0137 | ||||||
| Mef2c* | Transcription factor | Intron 3 | Same | 13 | 5q14 | AK_009139 |
| EKI | Ethanolamine kinase | 5′, 10.5 kb | Same | 6 | 12p12.2 | AK_044502 |
| BC060648 | Enzyme | 5′, 0.5 kb | Same | 4 | ND | BC_060648 |
| Arhh | GTPase | 5′, 2.2 kb | Same | 5 | 4p13 | AK_017885 |
| AK016052 | ND | Intron 5 | Same | 17 | ND | AK_016052 |
| AF397014 | ND | Intron 11 | Inverse | 13 | ND | AF_397014 |
| 0841 | ||||||
| Sfpi 1* | Transcription factor | Intron 1 | Same | 2 | 11p11.2 | BC003815 |
| CB520747 | ND | Intron 6 | Inverse | 4 | ND | CB_520747 |
| Cish | Signal transduction | Intron 1 | Same | 9 | 3p21.3 | BC_003783 |
| Wrnip1 | Helicase | 3′, 10 kb | Same | 13 | 6p25.2 | AK_050368 |
| Ifitm31 | Transmembrane protein | 5′, 11 kb | Inverse | 7 | ND | BC_002160 |
| Tde1 | Membrane protein | Intron 1 | Inverse | 2 | 20q13.1-13.3 | AK_031101 |
| 0935 | ||||||
| Hcph* | Tyrosine phosphatase | Intron 3 | Inverse | 6 | 12p13 | BC_012660 |
| 1494 | ||||||
| Rnf8 | Ring finger protein | Intron 1 | Inverse | 17 | ND | AJ_242721 |
| Rnf11 | Ring finger protein | Intron 1 | Same | 4 | 1pter-p22.1 | BC_010299 |
| Golga5 | Golgi protein | 3′, 24 kb | Same | 12 | 14q32.12-32.13 | BC_016883 |
| AK042193 | ND | exon 2 | Same | 1 | ND | AK_042193 |
| 1668 | ||||||
| AK054410 | ND | Intron 20 | Same | 9 | ND | AK_054410 |
| Soat1 | Sterol O-acyltransferase | Intron 1 | Same | 1 | 1q25 | L_42293 |
| AK017935 | ND | 5′, 17 kb | Inverse | 19 | ND | AK_017935 |
| 1865 | ||||||
| Plekha2* | pH domain | Intron 1 | Same | 8 | 8p11 | BC_010215 |
| Scm14 | Polycomb protein | Intron 1 | Inverse | 10 | ND | BC_043310 |
| Aif1 | Calcium binding | 5′, 0.5 kb | Inverse | 17 | 6p21.3 | AK_006184 |
| AK089567 | ND | 5′, 2 kb | Inverse | ND | ND | AK_089567 |
| Nfat5* | Transcription factor | 5′, 40 kb | Inverse | 8 | 16q22.1 | AF_200687 |
| 2208 | ||||||
| Elf4* | Transcription factor | 5′, 7 kb | Inverse | X | Xq26 | AF_016714 |
| Kif21b | Cytoskeleton binding | Intron 1 | Inverse | 1 | ND | AF_202893 |
| Runx1* | Transcription factor | Intron 1 | Inverse | 16 | 21q22.3 | AK_051758 |
| AU043488 | ND | Intron 1 | Inverse | 10 | ND | AU_043488 |
| 2938 | ||||||
| AK129203* | EST1 telomerase binding | Intron 7 | Inverse | 11 | ND | AK_129203 |
| Selp1 | Selectin ligand | 3′, 6 kb | Inverse | 5 | 12q24 | AK_089214 |
| AK039624 | ND | 5′, 66 kb | Inverse | 8 | ND | AK_039624 |
| 2987 | ||||||
| Dusp2 | Phosphatase | 5′, 14 kb | Same | 2 | 2q11 | L_11330 |
| AK016300 | tRNA deacylase | Intron 2 | Same | 12 | ND | AK_016300 |
| Irak3 | Signal transduction | Intron 1 | Same | 10 | 12q14.2 | AK_029057 |
| Ern1 | Signaling | Intron 1 | Inverse | 11 | 16p12 | AB_031332 |
| AK020256 | ND | Intron 1 | Inverse | 10 | ND | AK_020256 |
| 4564 | ||||||
| Cgef | GEF | Intron 3 | Inverse | 2 | 2q31-32 | AB_021132 |
| Nrf1 | Transcription factor | 5′, 2 kb | Inverse | 6 | 7q32 | AK_037697 |
| 0249 | ||||||
| Mef2o* | Transcription factor | Intron 3 | Same | 13 | 5q14 | AK_009139 |
| Hspa9a* | Heat shock protein | 5′, 0.7 kb | Inverse | 18 | 5q31.1 | D_17556 |
| BC042709 | ND | 5′, 26 kb | Same | 4 | ND | BC_042709 |
| 5413 | ||||||
| Sfpi1* | Transcription factor | Intron 1 | Same | 2 | 11p11.2 | BC_003815 |
| AK014882 | ND | 5′, 81 kb | Same | 10 | ND | AK_014882 |
| Tuba4 | Cytoskeleton | Intron 1 | Same | 1 | ND | BC_019959 |
| Vdac2 | Anion channel | Intron 2 | Inverse | 14 | 10q22 | U_30838 |
| BC042901 | ND | Exon 9 | Same | 7 | ND | BC_042901 |
| 6577 | ||||||
| Sfpi1* | Transcription factor | Intron 1 | Inverse | 2 | 11p11.2 | BC_003815 |
| AK008545 | ND | 3′, 4 kb | Same | X | ND | AK_008545 |
| Sbf1 | Antiphosphatase | Intron 1 | Same | 15 | ND | AK_129485 |
Viral integrations at Sfpi1 are located in the first intron based on mRNA (BC003815) and EST (BU698148, BU698834) sequencing results. Similarly, the viral integration at Runx1 is located in the first intron (AK051758, BF135151, U19601).
Genes known CISs for replication-competent murine leukemia viruses.14