Interaction of the exosites (I and II) of thrombin in substrate recognition (depicted as yes or no) and with cofactors that accelerate the substrate reactions
Substrate . | Cofactor . | Exosite I . | Exosite II . |
|---|---|---|---|
| Fibrinogen (Aα) | None | Yes | No |
| Fibrinogen (Bβ) | None | Yes | No |
| Fibrinogen | None | Yes | Yes |
| Factor V* | None | Yes | Yes |
| Factor VIII* | None | Yes | Yes |
| ADAMTS 13* | None | Yes | No |
| Factor XIII | Fibrin | With fibrin | No |
| PAR-1 | GpIbα | Yes | With GpIbα |
| Factor XI | GpIbα | Yes | With GpIbα |
| GpV | GpIbα | Uncertain | With GpIbα |
| Protein C | TM | With TM | With TM when CS is present |
| TAFI | TM | With TM | With TM when CS is present |
| AT | Heparin | No | With heparin |
| HCII | Heparin | Yes | With heparin |
Substrate . | Cofactor . | Exosite I . | Exosite II . |
|---|---|---|---|
| Fibrinogen (Aα) | None | Yes | No |
| Fibrinogen (Bβ) | None | Yes | No |
| Fibrinogen | None | Yes | Yes |
| Factor V* | None | Yes | Yes |
| Factor VIII* | None | Yes | Yes |
| ADAMTS 13* | None | Yes | No |
| Factor XIII | Fibrin | With fibrin | No |
| PAR-1 | GpIbα | Yes | With GpIbα |
| Factor XI | GpIbα | Yes | With GpIbα |
| GpV | GpIbα | Uncertain | With GpIbα |
| Protein C | TM | With TM | With TM when CS is present |
| TAFI | TM | With TM | With TM when CS is present |
| AT | Heparin | No | With heparin |
| HCII | Heparin | Yes | With heparin |
TM, thrombomodulin; CS, chondroitin sulphate; AT, antithrombin; HCII, heparin cofactor II.
Denotes more than 1 peptide bond is cleaved by thrombin.